{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:59:04Z","timestamp":1789559944952,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH135"],"award-info":[{"award-number":["ZR2024QH135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH264"],"award-info":[{"award-number":["ZR2024QH264"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myocardial infarction (MI), a leading global cause of death, triggers substantial cardiomyocyte loss and heart dysfunction. Current treatments, including guideline\u2010directed cardioprotective drugs and revascularization, face limitations such as poor durability, donor shortages, and immune rejection. Injectable hydrogels and cardiac patches offer promising avenues for post\u2010MI tissue regeneration, with electrical conductivity enhancing cardiac function. Curcumin\u2010gold nanoparticles (AuNPs) further mitigate inflammation, oxidative stress, and infarct size. This study integrates curcumin\u2010AuNPs with an electroconductive nanocomposite hydrogel via green chemistry, using curcumin as both a reducing and stabilizing agent. The resulting AuNPs exhibited a diameter of 32\u2009\u00b1\u20099\u2009nm and zeta potential of \u221229.6\u2009mV. Incorporation into the hydrogel yielded a porous nanocomposite (70%\u201380% porosity with interconnected pores, confirmed by SEM) that was biocompatible and multifunctional. In\u00a0vitro antioxidant assays showed dose\u2010dependent radical scavenging by AuNPs, peaking at 50\u2009\u03bcg\/mL. In isoproterenol\u2010induced myocardial injury rats, hydrogel\/AuNP administration significantly attenuated cardiac damage, reducing inflammation, oxidative stress, and infarct size while preserving function. These findings demonstrate that curcumin\u2010mediated AuNPs enable multifunctional, porous, antioxidant, and cardioprotective hydrogels with strong preclinical potential for MI repair and cardiovascular therapies.<\/jats:p>","DOI":"10.1002\/jbm.b.70056","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:42:30Z","timestamp":1774935750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biogenic\n                    <scp>AuNP<\/scp>\n                    \u2010Loaded Electroconductive Hydrogels: A Multifunctional Therapeutic Strategy for Isoproterenol\u2010Induced Myocardial Infarction"],"prefix":"10.1002","volume":"114","author":[{"given":"Cong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yang","sequence":"additional","affiliation":[{"name":"School Hospital, Qingdao University of Science &amp; Technology  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Qingdao University  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zibo Central Hospital  Zibo Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-8074","authenticated-orcid":false,"given":"Shubham","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Technical Sciences Western Caspian University  Baku Azerbaijan"},{"name":"Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University  Rajpura Punjab India"},{"name":"School of Mechanical and Automotive Engineering Qingdao University of Technology  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Karthikeyan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Sathyabama Institute of Science and Technology  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Thatoi","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Siksha \u2018O\u2019 Anusandhan (Deemed To Be University)  Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Department College of Engineering and Architecture, UMM Alqura University  Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lozanovic","sequence":"additional","affiliation":[{"name":"Department of Engineering University of Applied Sciences Campus Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.2713"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.18150"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.750510"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00093.2022"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.01.020"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-022-07402-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003670995-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-025-02357-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-025-03729-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S503445"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000004284"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202400835"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106439"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102538"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503686"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.103148"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2021.105123"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102387"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S328723"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102396"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2023.107200"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels11070530"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA05286F"},{"key":"e_1_2_12_25_1","first-page":"1","article-title":"Advancements in Gold Nanoparticle\u2010Infused 3D\u2010Printed Scaffolds for Cardiac, Muscle, and Bone Tissue Engineering","author":"Kabli S. A.","year":"2026","journal-title":"Regenerative Engineering and Translational Medicine"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB01462J"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-025-10660-9"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00955"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111705"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.12.022"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.11.034"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2020.100327"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040844"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA14567A"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA45345F"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.585163"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327120975131"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23693"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.067"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2024.103236"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2012.2191"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.8b00669"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2022.102235"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2021.08.111"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.002"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v11.i6.297"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00554.2011"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093660.86242.BB"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612827666210125155821"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.024"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-021-00824-7"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109617"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-97-4627-9_7"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.867497"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2013.03.001"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112775"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-019-09548-3"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174975"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.70056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:17:50Z","timestamp":1779337070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jbm.b.70056"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.70056","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70056"}}