{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:15Z","timestamp":1779340035897,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetic chronic wounds are difficult to heal due to persistent inflammation, excessive oxidative stress, and high infection risk. Herein, a multifunctional GelMA\u2010based microsphere co\u2010loaded with silver ions and curcumin (GelMA\u2010MS@Ag\/Cur) was developed as an advanced wound dressing for diabetic wound repair. The porous GelMA microspheres enabled efficient encapsulation and sustained release of Ag\n                    <jats:sup>+<\/jats:sup>\n                    and curcumin while maintaining good biocompatibility and controlled degradation. GelMA\u2010MS@Ag\/Cur exhibited broad\u2010spectrum antibacterial activity against both Gram\u2010positive and Gram\u2010negative bacteria and effectively reduced intracellular reactive oxygen species. The microspheres further promoted macrophage polarization toward the pro\u2010regenerative M2 phenotype. Mechanistically, GelMA\u2010MS@Ag\/Cur regulated the KEAP1\/Nrf2 signaling pathway and suppressed inflammation\u2010induced ferroptosis by modulating ACSL4, SLC7A11, and GPX4 expression, thereby preserving cellular redox homeostasis. In a diabetic rat full\u2010thickness wound model, GelMA\u2010MS@Ag\/Cur significantly accelerated wound closure, enhanced angiogenesis, collagen deposition, and tissue remodeling without observable systemic toxicity. This work provides a promising multifunctional strategy for diabetic chronic wound management.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70058","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:36:35Z","timestamp":1776656195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of\n                    <scp>GelMA<\/scp>\n                    Microspheres Loaded With Silver Ions and Curcumin for Antibacterial and Antioxidant Functions in Diabetic Chronic Wounds"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2559-4750","authenticated-orcid":false,"given":"Zhengnan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Bone and Soft Tissue Repair and Reconstructive Surgery The Second Hospital of Dalian Medical University  Dalian Liaoning 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