{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:41:55Z","timestamp":1778672515942,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoporosis is a highly prevalent systemic skeletal disease and a major risk factor for bone fractures. With the increase in population aging worldwide, the prevalence of osteoporosis has also increased. Nevertheless, there are unmet treatment demands for osteoporosis. Strontium plays a crucial role in bone biomineralization. Naringin is a flavanone glycoside with antiosteoporosis effects. Accordingly, this study synthesized strontium\u2010doped mesoporous hydroxyapatite (Hap\u2010Sr) particles and combined them with naringin (NHap\u2010Sr) for use in osteoporosis treatment. Specifically, mesoporous Hap particles were doped with Sr at various molar ratios (10%, 20%, and 30%) through coprecipitation and then combined with naringin (NHap\u2010Sr). These particles were characterized using X\u2010ray diffractometry, transmission electron microscopy, and Zetasizer analysis. Thermogravimetric analysis was conducted to determine the naringin loading efficiency. Various cell models were used to evaluate the potential cytotoxicity and effects of NHap\u2010Sr on bone turnover markers. The results indicated that Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ions were replaced with Sr\n                    <jats:sup>2+<\/jats:sup>\n                    ions, expanding the Hap crystal lattice. Moreover, Hap\u2010Sr20% was the optimal sample for the formation of a mesoporous structure with a particle size of 740\u20131600\u2009nm and a naringin loading efficiency of 8.5%. NHap\u2010Sr20% upregulated the mRNA expression levels of alkaline phosphatase, osteocalcin, osteoprotegerin, and receptor activator of nuclear factor kappa\u2010B ligand in osteoblast\u2010like cells without imposing cytotoxic effects or impairing mitochondrial membrane potential, demonstrating its ability to promote bone formation. Overall, combining Sr\u2010doped Hap and naringin is a promising osteoporosis treatment strategy.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70059","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:46:07Z","timestamp":1773384367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Strontium\u2010Doped Hydroxyapatite Incorporated With Naringin for Osteoporosis Treatment"],"prefix":"10.1002","volume":"114","author":[{"given":"Chih\u2010Yung","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Orthopedics En Chu Kong Hospital  New Taipei City Taiwan"},{"name":"School of Dental Technology, College of Oral Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Centre for Advancing Electronics Dresden Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Medizinische Fakult\u00e4t Universit\u00e4t Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-6671","authenticated-orcid":false,"given":"Feng\u2010Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering and College of Medicine National Taiwan University  Taipei 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