{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:08:42Z","timestamp":1779340122569,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2023AFB1046"],"award-info":[{"award-number":["2023AFB1046"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2019CFB407"],"award-info":[{"award-number":["2019CFB407"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Peripheral nerve injury (PNI) remains a major clinical challenge due to the limitations of autologous nerve grafting. Herein, a multifunctional composite nerve conduit was developed by integrating an oriented collagen\u2010grafted polylactic acid (PLA) electrospun scaffold with a conductive and anti\u2010inflammatory hydrogel to enhance peripheral nerve regeneration. The hydrogel was fabricated by chemically cross\u2010linking carboxymethyl chitosan (CMCS) and sodium carboxymethyl cellulose (CMC\u2010Na), incorporating polyaniline (PANI) to impart electrical conductivity and loading rhein (RH) for sustained anti\u2010inflammatory release. The PLA conduit was further modified with collagen and loaded with nerve growth factor (NGF), forming a structurally guided dual\u2010drug delivery system. The modified conduit exhibited improved hydrophilicity (water contact angle reduced from 107.7\u00b0 to 68.9\u00b0) and enhanced mechanical properties (Young's modulus of 9.88\u2009MPa). Sustained NGF and RH release reached 81.53% and 76.37% within 30\u2009days, respectively, with stable degradation over 72\u2009days. The conductive hydrogel displayed a uniform porous structure with high porosity (&gt;\u200970%) and an electrical conductivity of 12.19\u2009mS\/cm. The electrical conductivity of the composite nerve conduit is 3.27\u2009mS\/cm. In\u00a0vitro experiments demonstrated enhanced Schwann cell adhesion, neurite outgrowth, neuronal differentiation, anti\u2010inflammatory activity, and responsiveness to electrical stimulation. In\u00a0vivo studies using a rat sciatic nerve defect model confirmed significantly accelerated nerve regeneration. Overall, this electrically responsive, dual\u2010drug\u2010loaded hydrogel\u2010filled nerve conduit represents a promising alternative to autologous nerve grafts for peripheral nerve repair.<\/jats:p>","DOI":"10.1002\/jbm.b.70066","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:09:19Z","timestamp":1774861759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroactive Dual\u2010Drug Hydrogel\u2010\n                    <scp>PLA<\/scp>\n                    Conduit for Nerve Regeneration"],"prefix":"10.1002","volume":"114","author":[{"given":"Kebi","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry, Chemical Engineering and Life Sciences, State Key Laboratory of Advanced Glass Materials, Wuhan University of Technology  Wuhan 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