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Effective supportive care strategies are therefore essential to preserve skin integrity and prevent treatment interruption. Among available wound care options, hydrogel dressings have emerged as promising biomaterials due to their ability to maintain a moist environment, reduce transepidermal water loss, provide cooling relief, and enable atraumatic removal. This review aims to critically evaluate the role of hydrogel dressings in the management of RD by integrating current understanding of RD pathophysiology with advances in hydrogel design. The manuscript adopts a stage\u2010oriented approach, aligning natural, synthetic, and hybrid hydrogel systems with the evolving biological characteristics of irradiated skin. Comparative performance with conventional wound care materials and emerging innovations including bioactive, stimuli\u2010responsive, and multifunctional hydrogel platforms are also discussed. Although hydrogels demonstrate significant short\u2010term benefits in symptom control and wound healing, limitations such as mechanical constraints, cost considerations, and limited long\u2010term clinical evidence remain. Future research should prioritize well\u2010designed randomized trials, standardized outcome measures, and personalized guideline\u2010aligned application strategies to optimize their clinical integration. Hydrogel dressings represent a promising therapeutic platform in RD management, with potential to advance precision supportive oncology care.<\/jats:p>","DOI":"10.1002\/jbm.b.70070","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:53:28Z","timestamp":1776333208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Hydrogel Dressings in Management and Prevention of Radiation Dermatitis: A Comparative Review"],"prefix":"10.1002","volume":"114","author":[{"given":"Zintle","family":"Mbese","sequence":"first","affiliation":[{"name":"Department of Chemical and Earth Sciences University of Fort Hare  Alice South Africa"},{"name":"SAMRC Microbial Water Quality Monitoring Centre University of Fort Hare  Alice South Africa"},{"name":"DSTI\/NRF SARChI in Water Quality and Environmental Genomics University of Fort Hare  Alice South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omobola Oluranti","family":"Okoh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Earth Sciences University of Fort Hare  Alice South Africa"},{"name":"SAMRC Microbial Water Quality Monitoring Centre University of Fort Hare  Alice South Africa"},{"name":"DSTI\/NRF SARChI in Water Quality and Environmental Genomics University of Fort Hare  Alice South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jncd.jncd_57_24"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-025-01387-6"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-025-07700-y"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2020-4-7"},{"key":"e_1_2_15_6_1","article-title":"MASCC Clinical Practice Guidelines for the Prevention and Management of Acute Radiation Dermatitis: Part 1 Systematic Review","volume":"58","author":"Behroozian T.","year":"2023","journal-title":"Clinical Medicine"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02381"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05889-w"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.110846"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9729814"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211039681"},{"key":"e_1_2_15_12_1","first-page":"1","article-title":"Radiation\u2010Induced Skin Injury: Mechanisms, Clinical Manifestations, and Management","author":"Dadkhahfar S.","year":"2025","journal-title":"International Journal of Dermatology"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02831"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/CRST.CRST_209_20"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radmp.2020.02.004"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.17352\/2455-8605.000036"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-025-02624-9"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1645101"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-025-09178-2"},{"issue":"6","key":"e_1_2_15_20_1","first-page":"337","article-title":"Topical Corticosteroids: Choice and Application","volume":"103","author":"Stacey S. 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