{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:03:53Z","timestamp":1779987833331,"version":"3.53.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteomyelitis is a serious bone infection that causes inflammation and damage to the affected tissue. Conventional treatments include prolonged, high\u2010dose systemic antibiotic therapy, and debridement surgery, which may ultimately lead to amputation. Recent studies have been conducted on local antibiotic delivery systems, using biomaterials as potential candidates. One of the main advantages of local treatment is that it reduces recovery time, minimizes the side effects associated with high doses of antibiotics used in systemic treatment, and allows for targeted treatment of the affected area. This study aimed to evaluate the controlled release of a mixture of vancomycin and gentamicin using a calcium sodium silicate phosphate bioceramic as a drug delivery vehicle. This bioceramic is a biocompatible, osteoconductive, osteoinductive, and angiogenic biomaterial. In\u00a0vitro tests were conducted over 30\u2009days to assess its antimicrobial activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , using the Kirby\u2013Bauer and microdilution methods. The bioceramic effectively delivered the antibiotics, and the release of vancomycin was more sustained than that of gentamicin, as demonstrated by the inhibition zones against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , with diameters exceeding 20\u2009mm throughout the 30\u2010day study period. In the case of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E. coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , inhibition zones were observed until Day 15. Quantitative analysis confirmed a strong antibacterial effect against both microorganisms, achieving 100% growth inhibition during the evaluation period. In addition, four veterinary clinical cases and one control clinical case of osteomyelitis were treated with calcium\u2013sodium silicophosphate beads impregnated with vancomycin\/gentamicin. The patients recovered without complications 2\u2009months after implantation. The combination of antimicrobial efficacy and biocompatibility properties supports the development of this technology for both veterinary and, potentially, human clinical applications.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70074","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:55:16Z","timestamp":1778817316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Local Treatment of Osteomyelitis Using Sodium Calcium Silicophosphate Bioceramics for Antibiotic Delivery: In\u00a0Vitro Assays and Clinical Evaluation"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2260-2738","authenticated-orcid":false,"given":"Gabriela","family":"Mesa\u2010Mejia","sequence":"first","affiliation":[{"name":"Biology Program Faculty of Basic Sciences and Technologies  Armenia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-1140","authenticated-orcid":false,"given":"Johanny","family":"Aguill\u00f3n\u2010Osma","sequence":"additional","affiliation":[{"name":"Basic Sciences and Education Research Group (GICBE) University of Quind\u00edo  Armenia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-556X","authenticated-orcid":false,"given":"Johan","family":"Villada\u2010Ramos","sequence":"additional","affiliation":[{"name":"Basic Sciences and Education Research Group (GICBE) University of Quind\u00edo  Armenia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-2584","authenticated-orcid":false,"given":"July Andrea","family":"Rinc\u00f3n\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Director of Innovation and Development, DINSO\u2010MX  Lerma de Villada State of Mexico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Yair","family":"S\u00e1nchez\u2010Ort\u00edz","sequence":"additional","affiliation":[{"name":"Animalitos Hospitals  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-3044","authenticated-orcid":false,"given":"Fabiana Mar\u00eda","family":"Lora\u2010Suarez","sequence":"additional","affiliation":[{"name":"Basic Sciences and Education Research Group (GICBE) University of Quind\u00edo  Armenia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2016.04.01"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00932-19"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad070"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00284-13"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.17159\/2309\u20108309\/2021\/v20n1a4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/ORR.S50753"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2009.07.014"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2020.06.029"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34040"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-020-00622-8"},{"issue":"6","key":"e_1_2_13_12_1","first-page":"829","article-title":"The Use of a Biodegradable Antibiotic\u2010Loaded Calcium Sulphate Carrier Containing Tobramycin for the Treatment of Chronic Osteomyelitis: A Series of 195 Cases","volume":"96","author":"Ferguson J. 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