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The fabrication process combines the immersion technique for chitosan layer deposition with inert gas condensation (IGC) based on magnetron sputtering for the generation of CuNPs. This method enables precise control over nanoparticle size and concentration, allowing for their uniform incorporation into a biopolymer matrix. The resulting CS\/CuNPs\/CS multilayers exhibit excellent surface coverage, nanoscale roughness (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    of 30\u201365\u2009nm), and moderately hydrophilic character (contact angle of 30\u00b0\u201335\u00b0), which collectively support cell adhesion and proliferation. Surface characterization confirmed the stability and durability of the coatings, which can be attributed to prior substrate activation using Piranha solution and plasma treatment. Electrochemical tests demonstrated enhanced corrosion resistance of the CS\/CuNPs\/CS layers, with a reduced current density (4.10\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    \u2009mA\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) and good temporal stability. In\u00a0vitro studies using the MG\u201063 osteoblast\u2010like cell line indicated non\u2010cytotoxicity response of the coatings, confirming their plausible applicability in tissue engineering. Antibacterial assays revealed effective inhibition of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    growth and complete elimination of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    , highlighting the strong bactericidal potential of the developed system. Moreover, Cu ion release within the surface layer profiles obtained in Ringer's solution over a 7\u2010day period showed a predominantly linear release of copper ions, indicating a controlled and sustained antimicrobial effect. The ability to modulate chitosan layer thickness and nanoparticle loading during sequential deposition steps enables the customization of the coating properties to meet specific therapeutic requirements while minimizing nanoparticle usage. This strategy offers a promising platform for developing safe, effective, and tunable antibacterial coatings for biomedical implants.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70077","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:51:51Z","timestamp":1777265511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Hybrid Chitosan Coatings With Cu Nanoparticles on the Shape Memory\n                    <scp>NiTi<\/scp>\n                    Enabling Bactericidal Activity"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-9048","authenticated-orcid":false,"given":"Piotr","family":"Jab\u0142o\u0144ski","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Ceramics AGH University of Krakow  Krak\u00f3w Poland"},{"name":"Academic Centre for Materials and Nanotechnology AGH University of Krakow  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-4508","authenticated-orcid":false,"given":"Agnieszka","family":"Kyzio\u0142","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-8353","authenticated-orcid":false,"given":"Halina","family":"Krawiec","sequence":"additional","affiliation":[{"name":"Faculty of Foundry Engineering AGH University of Krakow  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-5244","authenticated-orcid":false,"given":"Victor","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Instituto de Nanociencia y Materiales de Aragon (INMA) CSIC, Universidad de Zaragoza  Zaragoza Spain"},{"name":"Networking Res. 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