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This study involved the design and assessment of surface\u2010functionalized mesoporous silica nanoparticles (MSNs) to improve the penetration and biofilm eradication efficacy of the synthetic antimicrobial and anti\u2010biofilm peptide\u2010276 (SAAP\u2010276) against established\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) biofilms. Fluorescently labeled MSN were altered with polyethylene glycol (PEG) and polypropylene imine (PPI) to examine their penetration profiles. Confocal Raman spectroscopy investigations demonstrated that PPI\u2010modified MSNs displayed enhanced biofilm penetration relative to PEG\u2010modified variants, despite possessing reduced entrapment effectiveness as for PEG\u2010PPI dual polymer conjugation. The conjugation of SAAP\u2010276 significantly improved biofilm eradication, with TMSN\u2010PPI\u2010PEG\u2010SAAP exhibiting the most efficiency due to its optimum antimicrobial peptide loading and uniform distribution throughout the biofilm matrix. Time\u2010dependent research demonstrated that extended exposure markedly diminished biofilm viability. Our findings underscore the pivotal importance of nanoparticle surface chemistry in biofilm interactions and indicate that MSN\u2010based AMP delivery systems can enhance biofilm eradication by enabling even and deeper penetration. These findings offer significant insights for the advancement of nanoparticle\u2010assisted antimicrobial peptide treatments targeting persistent biofilm infections.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70086","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:15:13Z","timestamp":1778130913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Delivery of Antimicrobial Peptide via Dual\u2010Functionalized Silica Nanoparticles Achieves Efficient\n                    <scp>\n                      <i>Staphylococcus aureus<\/i>\n                    <\/scp>\n                    Biofilm Eradication"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-4147","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Pamuk\u00e7u","sequence":"first","affiliation":[{"name":"Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences Izmir Katip \u00c7elebi University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-3467","authenticated-orcid":false,"given":"M. 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