{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:46:03Z","timestamp":1782477963703,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["n\u00b009\/2022"],"award-info":[{"award-number":["n\u00b009\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","award":["n\u00b054\/2022"],"award-info":[{"award-number":["n\u00b054\/2022"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013360","name":"Universidade do Extremo Sul Catarinense","doi-asserted-by":"publisher","award":["Edital n\u00b038\/2025"],"award-info":[{"award-number":["Edital n\u00b038\/2025"]}],"id":[{"id":"10.13039\/501100013360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Silver and gold nanoparticles promote antimicrobial activity and modulate inflammation in\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n \u2010infected wounds. Seventy\u2010two Wistar rats were randomly assigned to six experimental groups (\n n<\/jats:italic>\n \u2009=\u200912). Epithelial wounds were induced and contaminated with\n \n E. coli<\/jats:italic>\n <\/jats:styled-content>\n , followed by topical treatment for 8\u2009days. Treatment with Cur\u2010Ag NPs, Cur\u2010Au NPs, and Cur\u2010Ag\u2010Au NPs significantly increased wound contraction compared to the contaminated wound group (\n p<\/jats:italic>\n \u2009<\u20090.05). The Cur\u2010Ag\u2010Au NPs group showed a marked reduction in inflammatory infiltrate, accompanied by a significant decrease in IL\u20101\n \u03b2<\/jats:italic>\n levels (\n p<\/jats:italic>\n \u2009<\u20090.05) and increased levels of IL\u201010 and TGF\u2010\n \u03b2<\/jats:italic>\n (\n p<\/jats:italic>\n \u2009<\u20090.05). Oxidative stress parameters were significantly improved, with reduced nitrite levels (\n p<\/jats:italic>\n \u2009<\u20090.05) and increased glutathione (GSH) levels (\n p<\/jats:italic>\n \u2009<\u20090.05). Additionally, treated groups exhibited a significant reduction in\n \n E. coli<\/jats:italic>\n <\/jats:styled-content>\n colony\u2010forming units between days 3 and 7 (\n p<\/jats:italic>\n \u2009<\u20090.05), indicating antimicrobial activity. These findings demonstrate that biosynthesized AgNPs and AuNPs exert significant antimicrobial, anti\u2010inflammatory, and antioxidant effects, contributing to enhanced tissue repair in infected wounds.\n <\/jats:p>","DOI":"10.1002\/jbm.b.70102","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:01:16Z","timestamp":1782187276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silver and Gold Nanoparticles Promote Antimicrobial Activity and Modulate Inflammation in\n Escherichia coli<\/i>\n \u2010Infected Wounds"],"prefix":"10.1002","volume":"114","author":[{"given":"Rubya Pereira","family":"Zaccaron","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"},{"name":"Faculty of Sports Science Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusilania Tozi","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"de Roch Casagrande","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Ramos","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielli","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"da Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Aguiar","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"de Pieri","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz C\u00e9sar","family":"Guarita\u2010Souza","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Health Sciences, School of Medicine Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR) Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Andrez","family":"Machado\u2010De\u2010\u00c1vila","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-2538","authenticated-orcid":false,"given":"Anand","family":"Thirupathi","sequence":"additional","affiliation":[{"name":"Faculty of Sports Science Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-2257","authenticated-orcid":false,"given":"Paulo Cesar Lock","family":"Silveira","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Physiopathology, Program of Postgraduate in Science of Health Universidade do Extremo Sul Catarinense Crici\u00fama Brazil"},{"name":"Faculty of Sports Science Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731463"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2022.31.5.436"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011272"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8086"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040155"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35050-6"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/iraa205"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2021.100352"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137202"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110925"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S434693"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081574"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124761"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2024.2373304"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-023-02425-9"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.115067"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258221088709"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37481"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0290023"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00107-0"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00605-7"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01636-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90326-2"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-92880-3_16"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128581"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab021"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5433"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5369"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202405345"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2021.103246"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.102"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131948"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/08853282221109344"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10122453"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050700"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247098"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20010056"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.02.058"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2022.102558"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.13088"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00294"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27207059"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041905"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111993"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.70102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:52:10Z","timestamp":1782474730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.70102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jbm.b.70102"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.70102","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70102"}}