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By leveraging the pleiotropic anti\u2010inflammatory and tissue\u2010repair properties of RSV, the study aimed to overcome the rapid clearance and low efficacy associated with conventional oral gels and mouthwashes. Mucoadhesive hydrogels were formulated using Carbopol 934 and sodium alginate via a freeze\u2013thaw crosslinking technique. Four formulations (F1\u2013F4) were prepared and evaluated for morphology, swelling behavior, viscosity, mucoadhesive strength, drug entrapment efficiency, pH, in\u00a0vitro drug release, antimicrobial activity, cytocompatibility, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    therapeutic efficacy. Antimicrobial activity was assessed against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptococcus mutans<\/jats:italic>\n                    <\/jats:styled-content>\n                    (ATCC 10231) and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MTCC 2940), while cytocompatibility was determined using an MTT assay on fibroblast cells. The formulated mucoadhesive hydrogel showed good swelling behavior, thermal stability, and controllable biodegradability. The four formulations (F1, F2, F3, and F4) exhibited significant entrapment efficiency (72.14%\u2009\u00b1\u20091.5% to 95.12%\u2009\u00b1\u20090.28%), and the pH was 6.7. The optimized formulation (F3) demonstrated sustained RSV release of 96.8%\u2009\u00b1\u20091.4% over 8\u2009h. We found that F3 may inhibit the growth of both\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptococcus mutans<\/jats:italic>\n                    <\/jats:styled-content>\n                    (ATCC 10231\n                    <jats:italic>)<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MTCC 2940) (MRSA), which are common aphthous ulcer infectious bacteria. Cytocompatibility studies confirmed that F3 supported fibroblast viability and enhanced cell proliferation. In\u00a0vivo evaluation further demonstrated improved healing of oral ulcers, supported by histopathological findings indicating enhanced tissue regeneration and reduced inflammation. The RSV\u2010loaded mucoadhesive hydrogel (F3) exhibited high drug entrapment, sustained release, effective antimicrobial activity, and excellent biocompatibility, leading to significant therapeutic efficacy in an animal model. These findings suggest that the developed hydrogel is a promising and safe alternative for the treatment of aphthous ulcers, warranting further clinical investigation.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70108","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:31:17Z","timestamp":1781083877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation and Characterization of Biopolymeric\u2010Based Orally Dissolving Mucoadhesive Hydrogels Loaded With Rosuvastatin for the Effective Treatment of Aphthous Ulcer"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4260-1131","authenticated-orcid":false,"given":"Ishika","family":"Dey","sequence":"first","affiliation":[{"name":"Bengal College of Pharmaceutical Sciences and Research  Durgapur West Bengal 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