{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:46:03Z","timestamp":1782477963761,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate whether recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) or bisphosphonate added to synthetic block bone substitute influences new bone formation and grafting material degradation patterns. In a rabbit calvarial model, four critical\u2010size bone defects were created and treated with a saline\u2010soaked synthetic bone block (SBB group), bisphosphonate\u2010soaked synthetic bone block (BPS group), rhBMP\u20102\u2010soaked synthetic bone block (BMP group), or left untreated as control (control group). At 8\u2009weeks, synchrotron\u2010based micro\u2010computed tomography (micro\u2010CT) and histological analyses were performed. All outcomes were evaluated separately in intrabony areas, embedded within the native bone, and extrabony areas, extending beyond the bone surface. Synchrotron\u2010based micro\u2010CT analysis revealed limited resorption of the synthetic bone block across all groups, as the mean percentages of synthetic bone block resorption of the SBB group, BPS group, and BMP group were 8.56%, 11.13%, and 9.11%, respectively, with no significant differences. The cylindric morphology of the grafts was preserved even in the exophytic extrabony portion. Histological evaluation showed that BMP significantly enhanced new bone formation, particularly in the intrabony area (2.65\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    for SBB group, 1.37\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    for BPS group, and 4.41\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    for BMP group in mean). Despite these differences in osteogenic activity, neither bisphosphonate nor rhBMP\u20102 markedly increased graft resorption, as residual bone graft material was well preserved. Synthetic bone blocks could provide volume stability in both intrabony and extrabony regions, regardless of the addition of bioactive mediators. RhBMP\u20102 enhanced bone regeneration, though.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70109","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:00:01Z","timestamp":1780642801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resorption Pattern and Bone Regeneration Using a Synthetic Bone Substitute Block With or Without\n                    <scp>rhBMP<\/scp>\n                    \u20102 and Bisphosphonates: An in Vivo Experiment"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6885-8786","authenticated-orcid":false,"given":"Seung Ha","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-5646","authenticated-orcid":false,"given":"Young Woo","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Hospital Veterans Health Service Medical Center  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-8036","authenticated-orcid":false,"given":"Seung\u2010Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-014X","authenticated-orcid":false,"given":"Jae\u2010Hong","family":"Lim","sequence":"additional","affiliation":[{"name":"Pohang Accelerator Laboratory, POSTECH  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-1320","authenticated-orcid":false,"given":"Ronald","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-7447","authenticated-orcid":false,"given":"Daniel","family":"Thoma","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul South Korea"},{"name":"Clinic of Reconstructive Dentistry, Center of Dental Medicine, University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6371-4172","authenticated-orcid":false,"given":"Ui\u2010Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry  Seoul South 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