{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:27:26Z","timestamp":1786112846293,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["INAE\u2010SERB: INAE\/121\/AKF\/20"],"award-info":[{"award-number":["INAE\u2010SERB: INAE\/121\/AKF\/20"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The biocompatibility of bioresorbable ceramics is critically influenced by the interplay between ceramic resorption and bone formation. This study presents a mathematical framework to quantitatively model the competition between these processes using beta\u2010tricalcium phosphate (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010TCP) as a model system. Such a framework incorporates the paracrine and autocrine signaling interactions among osteoblasts and osteoclasts. While analysing in\u00a0vivo data (sheep model), the temporal dynamics of bone formation and ceramic resorption are evaluated. The model predictions align closely with the experimental results, capturing key biophysical mechanisms. Apart from fitting with empirical models, the bone growth kinetics data of the published studies follow Hill's model closely, which is regarded as the foundation of quantitative pharmacology. While analysing its physiological relevance, the parametric sensitivity analysis reveals the dominant influence of osteoclast removal rates and specific signaling pathways (osteoblast\u2010to\u2010osteoblast and osteoblast\u2010to\u2010osteoclast) on bone growth. The competition between bone growth and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010TCP resorption leads to a cross\u2010over at 6\u2009weeks, which correlates well with the time period to produce the half\u2010of\u2010the\u2010maximum bone growth as per Hill's model. These findings provide insights into optimising the design of bioresorbable ceramics for clinical applications, emphasising the tailoring of resorption rates to support bone growth, in\u00a0vivo.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70115","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:53:30Z","timestamp":1784084010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Model Explaining the Competition Between Calcium Phosphate Resorption and Bone Formation in Sheep Model"],"prefix":"10.1002","volume":"114","author":[{"given":"Bikramjit","family":"Basu","sequence":"first","affiliation":[{"name":"Laboratory for Biomaterials Science and Translational Research, Materials Research Centre Indian Institute of Science  Bangalore India"},{"name":"Research &amp; Knowledge Transfer, RMS Foundation  Bettlach Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susantika","family":"Paik","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials Science and Translational Research, Materials Research Centre Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials Science and Translational Research, Materials Research Centre Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bohner","sequence":"additional","affiliation":[{"name":"Research &amp; Knowledge Transfer, RMS Foundation  Bettlach Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.03.026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.05.051"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.01.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.08.007"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.07.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.030"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.03.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33962"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchar.2016.06.030"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchar.2016.08.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v028a21"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2017.02.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00157-1"},{"key":"e_1_2_10_16_1","first-page":"55","volume-title":"Scientific Computing","author":"Hindmarsh A. C.","year":"1983"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.07.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00407-012-0098-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1011500"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/b707171j"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1004769820545"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JMSC.0000020008.76515.bd"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/jcis.1997.4846"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/la001730n"},{"key":"e_1_2_10_25_1","volume-title":"Biomaterials Science and Tissue Engineering: Principles and Methods","author":"Basu B.","year":"2017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00252"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1909.sp001344"},{"key":"e_1_2_10_28_1","first-page":"iv","article-title":"The Possible Effects of the Aggregation of the Molecules of Haemoglobin on Its Dissociation Curves","volume":"40","author":"Hill A. V.","year":"1910","journal-title":"Journal of Physiology (London)"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-5-28"},{"key":"e_1_2_10_30_1","volume-title":"Biomaterials for Musculoskeletal Regeneration: Concepts","author":"Basu B.","year":"2017"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34752"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.070"},{"key":"e_1_2_10_33_1","volume-title":"Biomaterials for Musculoskeletal Regeneration: Applications","author":"Basu B.","year":"2017"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b00488"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.70115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:32:34Z","timestamp":1785947554000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jbm.b.70115"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.70115","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70115"}}