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Here, we optimized polycaprolactone (PCL) short nanofibers production and combined them with a soft hydrogel based on\n                    <jats:italic>kappa\u2010<\/jats:italic>\n                    carrageenan and gelatin type B (kCGb) to perform umbilical cord pericyte (UCP) delivery and promote re\u2010endothelialization of injured blood vessels. Electrospinning of PCL identified 12.5% w\/v concentration, 0.5\u2009mL\/h flow rate, 21\u2009kV voltage, and 6.8\u2009m\/s drum collector speed as optimal parameters for aligned beadless nanofibers. Coaxial PCL\/gelatin type A (Ga) fibers were successfully produced with diameters of 180\u2013190\u2009nm (core) and 225\u2013245\u2009nm (shell). The Ga acts as a temporary shell, which was removed during postfabrication processing by washing the nanofibers with deionized water (DIW) at 37\u00b0C for 30\u2009min. Mechanical cryostat cutting generated short nanofibers (~75\u2009\u03bcm\u2009\u00b1\u200928\u2009\u03bcm) with higher yields from coaxial mats (2\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \u2009fibers\/mL\u2009\u00b1\u20091.6\u2009\u00d7\u200910\n                    <jats:sup>5<\/jats:sup>\n                    fibers\/mL) compared to single PCL mats (5\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    \u2009fibers\/mL\u2009\u00b1\u20091.3\u2009\u00d7\u200910\n                    <jats:sup>4<\/jats:sup>\n                    \u2009fibers\/mL). kCGb hydrogel showed a significant improvement in mechanical properties when reinforced with short PCL nanofibers. The recovery percentage, measured using rheology, increased from 12.1%\u2009\u00b1\u20090.3% to 90.9%\u2009\u00b1\u20090.4% when a small amount (0.05\u2009wt%) of short PCL nanofibers was added. The injection force using clinically relevant needles of 0.5kC2Gb0.05PCL was about ~37\u2009N, and there was no significant reduction in UCPs viability after injection up to 1\u2009week of culture. Injection delivery of kCGbPCL mixed with UCPs (1\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \u2009cells\/mL) in an ex\u00a0vivo model of porcine artery injury led to a marked improvement in endothelial coverage from 47.2%\u2009\u00b1\u200919.1% in the injured artery to 76.5%\u2009\u00b1\u200913.2% after cell therapy, with a restoration index of about 89.8% after 1\u2009week of culture. These results represent a further step toward developing physically cross\u2010linked and mechanically stable injectable scaffolds for different applications, such as drug delivery, 3D printing, in\u00a0vitro modeling, and tissue engineering.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70126","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:46:34Z","timestamp":1787208394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shear\u2010Thinning Composite Hydrogel Incorporating Polycaprolactone (\n                    <scp>PCL<\/scp>\n                    ) Short Nanofibers for Cell Therapy Applications"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-6082","authenticated-orcid":false,"given":"Akram Jassim","family":"Jawad","sequence":"first","affiliation":[{"name":"School of Biosciences University of Surrey  Guildford 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