{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:26:59Z","timestamp":1786112819359,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020275","name":"Vilnius University","doi-asserted-by":"publisher","award":["MSF\u2010JM\u20109\/2021"],"award-info":[{"award-number":["MSF\u2010JM\u20109\/2021"]}],"id":[{"id":"10.13039\/501100020275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To evaluate late\u2010stage bone regeneration in rabbit calvarial critical\u2010size defects treated with 3D\u2010printed PLA\/HA\/CDHA gyroid scaffolds with unit\u2010cell periods of 0.9 or 1.2\u2009mm, versus empty defects. In this randomized exploratory within\u2010animal preclinical study, 12 calvarial defects were created in New Zealand White rabbits and allocated to PLA\/HA\/CDHA gyroid scaffolds with a 0.9\u2010mm unit\u2010cell period (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), PLA\/HA\/CDHA gyroid scaffolds with a 1.2\u2010mm unit\u2010cell period (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094), or empty negative controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093). Healing was assessed after 12\u2009weeks by micro\u2010computed tomography and histomorphometry. At 12\u2009weeks there was no statistically detectable difference in regenerated bone volume between groups; given the limited sample size and wide variances, this finding does not constitute evidence of equivalence. Both scaffold designs supported bone formation within the defects and showed descriptively thicker peripheral bone rims on histology than empty controls. Histomorphometric new bone area was 2.30\u2009\u00b1\u20091.16\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    in the 0.9\u2010mm group and 2.43\u2009\u00b1\u20091.15\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    in the 1.2\u2010mm group, compared with 1.17\u2009\u00b1\u20091.10\u2009mm\n                    <jats:sup>2<\/jats:sup>\n                    in controls. Vascularized surface was descriptively higher in scaffold\u2010treated defects, with the highest mean value in the 1.2\u2010mm group. Spatial analyses suggested more center\u2010directed bone advancement in scaffold\u2010treated defects, particularly in the 1.2\u2010mm group. Spatial analyses suggested a scaffold\u2010associated bottom\u2010to\u2010top (dural\u2010side) pattern of bone advancement, while the two scaffold architectures performed similarly across bone and vascular outcomes. Although bone volume did not differ significantly between the 0.9\u2010 and 1.2\u2010mm groups, equivalence cannot be inferred. Further longitudinal studies are needed to optimize architected composite scaffolds for craniofacial bone regeneration and dental augmentation.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70128","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:51:26Z","timestamp":1783486286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large\u2010Pore\n                    <scp>3D<\/scp>\n                    \u2010Printed\n                    <scp>PLA<\/scp>\n                    \/\n                    <scp>HA<\/scp>\n                    \/\n                    <scp>CDHA<\/scp>\n                    Gyroid Scaffolds for Bone Regeneration: Effect of Unit\u2010Cell Period in a Rabbit Calvarial Defect Model"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0861-0009","authenticated-orcid":false,"given":"Milda","family":"Vitosyte","sequence":"first","affiliation":[{"name":"Institute of Odontology, Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidijus","family":"Simoliunas","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milda","family":"Alksne","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Didziokas","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Interdisciplinary Nanoscience Centre (iNano) Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Manuel","family":"Mart\u00ednez\u2010C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Anatom\u00eda Patol\u00f3gica Comparadas Universidad de Murcia  Murcia Spain"},{"name":"Plataforma de patolog\u00eda IMIB\u2010Pascual Parrilla  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Mart\u00ednez","family":"Abenza","sequence":"additional","affiliation":[{"name":"Plataforma de patolog\u00eda IMIB\u2010Pascual Parrilla  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mantas","family":"Liudvinaitis","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Life Sciences Center Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dovile","family":"Proskute","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otorhinolaryngology and Santaros Departament of Maxillofacial Surgery Vilnius University Hospital Santaros Clinics  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vygandas","family":"Rutkunas","sequence":"additional","affiliation":[{"name":"Institute of Odontology, Faculty of Medicine Vilnius University  Vilnius Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Gendviliene","sequence":"additional","affiliation":[{"name":"Institute of Odontology, Faculty of Medicine Vilnius University  Vilnius 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