{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:27:14Z","timestamp":1786112834460,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSCT\u2010112\u20102221\u2010E\u2010239\u2010016"],"award-info":[{"award-number":["NSCT\u2010112\u20102221\u2010E\u2010239\u2010016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSCT\u2010114\u20102221\u2010E\u2010239\u2010016\u2010MY3"],"award-info":[{"award-number":["NSCT\u2010114\u20102221\u2010E\u2010239\u2010016\u2010MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Skin wound repair involves coordinated cellular activities regulated by both biochemical and bioelectrical cues. In this study, an electroactive hydrogel system based on oxidized hyaluronic acid (oxi\u2010HA) crosslinked with adipic dihydrazide (ADH) and incorporated with polypyrrole (PPy) was developed and systematically evaluated. The effects of PPy incorporation on hydrogel structure, physicochemical properties, electrochemical behavior, and cellular responses were investigated. FTIR and SEM analyses confirmed successful PPy incorporation within the oxi\u2010HA network, while preserving an interconnected porous structure at low PPy content. Increasing PPy concentration reduced swelling capacity and altered degradation behavior, indicating a transition toward a denser network. Electrochemical measurements demonstrated a PPy\u2010dependent increase in conductivity and electrochemical behavior, accompanied by increased peak\u2010to\u2010peak separation (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>p<\/jats:sub>\n                    ) at higher PPy content, indicating changes in electrochemical behavior that warrant further investigation. In\u00a0vitro studies showed that hydrogels with moderate PPy incorporation (PPy\u20104) maintained high cytocompatibility (&gt;\u200995%) and supported fibroblast proliferation, whereas excessive PPy content was associated with reduced cell viability. Under daily low\u2010intensity electrical stimulation (20\u2009\u03bcA, 5\u2009min\/day), PPy\u20104 hydrogels further enhanced fibroblast proliferation, migration, and upregulated wound\u2010healing\u2013related gene expression (PDGF\u2010A, FGF\u20102, and TGF\u2010\u03b21). These results indicate that the incorporation of in\u00a0situ polymerized PPy modulates the structural and electrochemical properties of oxi\u2010HA hydrogels and is associated with composition\u2010dependent differences in cellular responses under electrical stimulation. This study provides an in\u00a0vitro proof\u2010of\u2010concept for the development of oxi\u2010HA\/PPy\/ADH hydrogel systems with composition\u2010dependent electroactive properties.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70130","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:47:47Z","timestamp":1783997267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polypyrrole Incorporation Modulates the Structural, Electrochemical, and Biological Performance of Oxidized Hyaluronic Acid Hydrogels"],"prefix":"10.1002","volume":"114","author":[{"given":"Yu\u2010Chun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National United University  Miaoli Taiwan, ROC"},{"name":"International Master Program of Translational Medicine National United University  Miaoli Taiwan, 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