{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:01:53Z","timestamp":1790323313155,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Extracellular amyloid plaques from A\u03b2 accumulation and intracellular neurofibrillary tangles (NFTs) from hyperphosphorylated Tau (p\u2010Tau), both leading to neuronal dysfunction, synapse loss, and cognitive decline. Nonetheless, achieving an effective therapeutic outcome is challenging due to the limited drug bioavailability through the blood\u2013brain barrier (BBB) and the complex microenvironment within the brain. This study proposes MM\u2010TA for the synergistic treatment of AD, utilizing mesoporous manganese (MM) as a nanocarrier to deliver a LK7 (A\u03b2\u2010inhibiting peptide) and a DAA (amino acid\u2010peptide) that inhibits Tau\u2010related fibrils formation. A biomimetic nanocarrier (MM\u2010LD@4CM termed as MLDC) encapsulated with 4T1 cell membranes (4CM) was developed, inspired by 4T1 cells' ability to facilitate BBB penetration. Following traversal of the BBB, MLDC concurrently prevented Tau phosphorylation and suppressed A\u03b2 aggregation. Furthermore, by leveraging MM's catalase\u2010mimetic properties, MLDC mitigated oxidative stress and altered the microenvironment associated with AD progression. In contrast to the singular therapeutic agent, MLDC ameliorated nerve damage and enhanced cognitive function in AD mice by reducing A\u03b2 oligomers, phosphorylated Tau, and inflammation, thereby providing a synergistic therapeutic approach with significant potential for effective AD treatment.<\/jats:p>","DOI":"10.1002\/jbm.b.70131","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:48:02Z","timestamp":1787968082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication of Mesoporous Manganese Nanoparticles Incorporated A\u03b2\u2010Peptide Inhibits A\u03b2 Aggregation and Alleviates Neuroinflammation Against Alzheimer's Disease"],"prefix":"10.1002","volume":"114","author":[{"given":"Haipeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jin Hua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanchen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jin Hua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4517-0196","authenticated-orcid":false,"given":"Yaming","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jin Hua China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01389-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04384-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/neurolint17100166"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251360321"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.118737"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.172489.1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae234"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp2564"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X251328537"},{"key":"e_1_2_10_11_1","article-title":"Targeting Inflammation in Alzheimer's Disease: Insights Into Pathophysiology and Therapeutic Avenues: A Comprehensive Review","volume":"39","author":"Topalis V.","year":"2025","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdad2020015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04333-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-02886-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00166.2025"},{"key":"e_1_2_10_16_1","first-page":"138728772513422","article-title":"The Interaction Between Neurotransmitter Receptor Activity and Amyloid\u2010\u03b2 Pathology in Alzheimer's Disease","volume":"106","author":"Nong Y.","year":"2025","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15060824"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.115049"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00227-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04721-y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54878-8"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2025.02.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2025.06.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijper.20251674"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.5c00997"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB00911A"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c18528"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10340-024-01820-y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156547"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03481-0"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94907175"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2022.100262"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115049"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122703"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122666"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2025.2519867"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.5c03474"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108981"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.123042"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.21608\/aijpms.2025.304451.1281"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119990"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138083"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2025.106764"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163340"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.06.034"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909369"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201013896\u20107"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091976"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.074"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010019\u201001780\u2010w"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26199793"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00808"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:24:06Z","timestamp":1790321046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jbm.b.70131"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.70131","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70131"}}