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Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H\n                    <jats:sub>2<\/jats:sub>\n                    S is a small gas with a short half\u2010life, making it extremely capable of penetrating through cell membranes quite easily and fast via gas exchange. This fundamental small molecule possesses many physiological and pathological functions and is found in almost every mammalian system, such as the cardiovascular system, the integumentary\/skin system, the neural system, the gastrointestinal tract system, and the skeletal system. As a therapeutic, the gas can modulate biological pathways, maintain homeostasis under physiological conditions, and mediate several pathological processes, thereby supporting cardioprotective applications. Due to the ever\u2010increasing cardiovascular complications, especially concerning myocardial infarction and atherosclerosis, more and more patients are suffering from heart failure, and in some cases, this results in death. To remedy the progression of cardiovascular complications and cardiovascular disease burden as a whole, H\n                    <jats:sub>2<\/jats:sub>\n                    S has emerged as a potential candidate to mediate this problem. This review will specifically focus on the therapeutic potential of H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010releasing platforms tailored to aid in cardiovascular applications.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70133","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T03:46:56Z","timestamp":1786074416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Therapeutic Potential of\n                    <scp>\n                      H\n                      <sub>2<\/sub>\n                      S\n                    <\/scp>\n                    \u2010Releasing Platforms in Cardiovascular Applications"],"prefix":"10.1002","volume":"114","author":[{"given":"Tia N.","family":"Shorter","sequence":"first","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-5448","authenticated-orcid":false,"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering, College of Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd19.220347"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.001"},{"key":"e_1_2_13_6_1","volume-title":"World Heart Report 2023: Confronting the World's Number One Killer","author":"Di Cesare M.","year":"2023"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"e_1_2_13_8_1","first-page":"21","article-title":"Cardiovascular Disease (CVD): Assessment, Prediction and Policy Implications","volume":"21","author":"Rehman S.","year":"2021","journal-title":"BMC Public Health"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-117"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.05.033"},{"key":"e_1_2_13_12_1","volume-title":"Projections of Cardiovascular Disease Prevalence and Costs: 2015\u20132035","author":"Khavjou O.","year":"2016"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM02154G"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1278"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0148-z"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-016-0274-8"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.201566"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm-2017-110888"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.01.036"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1071338"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.177592"},{"key":"e_1_2_13_22_1","unstructured":"\u201cFDA\u2010Approved Devices That Help Keep the Heart Beating \u201daccessed 2024\u201005\u201003 https:\/\/www.fda.gov\/consumers\/consumer\u2010updates\/fda\u2010approved\u2010devices\u2010help\u2010keep\u2010heart\u2010beating."},{"key":"e_1_2_13_23_1","volume-title":"Hemocompatibility of Biomaterials for Clinical Applications: Blood\u2010Biomaterials Interactions","author":"Siedlecki C. 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