{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:17:54Z","timestamp":1787822274698,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2417100"],"award-info":[{"award-number":["2023YFC2417100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Biological reactions to wear particles from artificial joint prostheses can lead to osteolysis, ultimately resulting in aseptic loosening and implant failure, which affect the longevity of the prosthesis and the patient's quality of life. Polyether\u2010ether\u2010ketone (PEEK) has emerged as a key area of research in orthopedic implant materials due to its excellent wear resistance and biomechanical compatibility with human bone tissue. In this study, we conducted a 10\u2010million\u2010cycle simulator wear test on hip artificial joints with polyetheretherketone\u2010on\u2010highly cross\u2010linked polyethylene (PEEK\u2010on\u2010HCLPE) bearing couplings for the first time. The results indicated the total wear loss of the highly cross\u2010linked polyethylene (HCLPE) liners was 34.03\u2009\u00b1\u20093.2\u2009mg (~2.96\u2009mg\/MC or 3.18\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    \/MC after linear fitting). The physicochemical properties of the mixed particles indicated a predominant particle size distribution ranging from 0.1 to 0.5\u2009\u03bcm. Pure PEEK or HCLPE particles with the similar size range (maximum size: 0.5\u2009\u03bcm) were generated by an EXAKT grinding system, followed by vacuum filtration with precision pore\u2014size membranes for the biocompatibility experiments. In\u00a0vitro immunological assays showed that 0.1 to 0.5\u2009\u03bcm PEEK particles may induce a relatively weaker immune inflammatory effect than 0.1 to 0.5\u2009\u03bcm HCLPE particles. In conclusion, the PEEK\u2010on\u2010HCLPE bearing couple has been demonstrated to have acceptable biosafety and a wear rate suitable for use as a potential hip replacement implant.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70139","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:53:10Z","timestamp":1786521190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wear Rate, Particle Morphology, and Biocompatibility of Polyether\u2010Ether\u2010Ketone Femoral Heads Against Highly Cross\u2010Linked Polyethylene Acetabular Cups in Hip Prosthetic Couples"],"prefix":"10.1002","volume":"114","author":[{"given":"Fei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wu","sequence":"additional","affiliation":[{"name":"Suzhou SinoMed Biomaterials Co., Ltd  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-5605","authenticated-orcid":false,"given":"Zhuocheng","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-3088","authenticated-orcid":false,"given":"Xu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikai","family":"Hua","sequence":"additional","affiliation":[{"name":"Orthotek Lab, School of Mechatronic Engineering and Automation Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Physics China University of Mining and Technology  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-3293","authenticated-orcid":false,"given":"You","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453679408993734"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0753"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000238813.95035.1b"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.00695"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.128"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110060"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2018.18.e8"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"E18","article-title":"Metallosis After Metal\u2010On\u2010Polyethylene Total Hip Arthroplasty","volume":"37","author":"Cipriano C. 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