{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:17:58Z","timestamp":1787822278572,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Critical\u2010sized bone defects (CSDs) represent a major clinical challenge due to their limited self\u2010healing capacity. Conventional hydrogels incorporating crystalline hydroxyapatite (HA) often fail to recapitulate the hierarchical nanostructure of native bone, leading to suboptimal regeneration outcomes. To overcome this, we developed a biomimetic hydrogel by molecularly integrating amorphous calcium phosphate oligomers (CPO) into gelatin methacryloyl (GelMA), enabling a bone\u2010like organic\u2013inorganic hybrid network. This composite exhibits outstanding performance: an ultimate strength of 192\u2009kPa at 18\u2009wt% CPO confirms robust mechanical reinforcement, while 54% mass retention after 56\u2009days underscores exceptional degradation resistance and dose\u2010dependent bioactivity, evidenced by a two\u2010fold upregulation of alkaline phosphatase (ALP) activity. The amorphous CPO facilitates biomimetic HA nucleation within the GelMA matrix, mimicking the natural mineralization process. In a rat calvarial CSD model, the hydrogel promoted 60% bone volume regeneration within 12\u2009weeks, significantly outperforming conventional composites, through seamless host integration, vascularized trabecular bone formation, and a collagen\u2013mineral hierarchy resembling native osteogenesis. This study establishes CPO as a transformative component that converts passive scaffolds into bioactive osteogenic microenvironments, offering a clinically viable strategy for complex bone regeneration.<\/jats:p>","DOI":"10.1002\/jbm.b.70141","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:27:35Z","timestamp":1786760855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteogenic\n                    <scp>GelMA<\/scp>\n                    \/Calcium Oligophosphate Composite Hydrogel for Bone Regeneration"],"prefix":"10.1002","volume":"114","author":[{"given":"Yue","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Southwest Hospital, Army Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Nano\/Micro Composite Materials and Devices, Chongqing Engineering Laboratory of Nano\/Micro Biomedical Detection Technology Chongqing University of Science and Technology  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology &amp; 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National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices &amp; Beijing Key Laboratory for Intelligent Biomanufacturing and Regeneration of Craniofacial Tissues &amp; NHC Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congyan","family":"Xia","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory of Nano\/Micro Composite Materials and Devices, Chongqing Engineering Laboratory of Nano\/Micro Biomedical Detection Technology Chongqing University of Science and Technology  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Peking University School and Hospital of Stomatology &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; 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