{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:17:56Z","timestamp":1787822276680,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62574177"],"award-info":[{"award-number":["62574177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Effective skin repair and photoprotection require multifunctional, simple, and ready\u2010to\u2010use biomaterials. We focused on natural tea trichomes (TH), a class of plant\u2010derived microfilaments abundantly distributed on tea leaves, as a potential candidate biomaterial that fulfills these criteria. TH exhibited a uniform fibrous morphology with a diameter of approximately 9.1\u2009\u03bcm and a high polyphenol content of 176\u2009\u03bcg\/mg. In\u00a0vitro ABTS\n                    <jats:sup>+<\/jats:sup>\n                    and DPPH assays confirmed its effective radical scavenging capacity. In\u00a0vivo studies demonstrated rapid hemostasis with negligible hemolysis, underscoring its biosafety. In a murine full\u2010thickness wound model, TH significantly accelerated tissue regeneration, achieving 88.9% wound closure on day 10 versus 77.6% in controls, by promoting M1\u2010to\u2010M2 macrophage polarization, enhancing collagen deposition, and stimulating hair follicle neogenesis. Furthermore, TH, whether applied alone or blended into a hyaluronic acid (HA) matrix, effectively mitigated UV\u2010induced epidermal hyperplasia, collagen degradation, and inflammatory cytokine expression. This work demonstrates that TH can serve as a sustainable, multifunctional platform for skin repair, with regenerative and photoprotective properties as its primary demonstrated functions.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70147","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:05:52Z","timestamp":1786759552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Trichomes as a Functional Biomaterial Platform With Photoprotective and Regenerative Properties"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-5234","authenticated-orcid":false,"given":"Jianmei","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine in Senile Diseases Control, School of Traditional Chinese Medicine, Faculty of Medicine Yangzhou University  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-7462","authenticated-orcid":false,"given":"Zongguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Microelectronics Industry Research Institute, School of Physics Science and Technology, Yangzhou University  Yangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"e_1_2_9_3_1","first-page":"3974","article-title":"Inflammatory Molecules Associated With Ultraviolet Radiation\u2010Mediated Skin Aging","volume":"22","author":"Ansary T. 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