{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:01:50Z","timestamp":1790323310120,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R43AR083326"],"award-info":[{"award-number":["1R43AR083326"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Massive, irreparable rotator cuff tears affect a significant patient population and often require invasive procedures such as allograft patch augmentation, superior capsule reconstruction, and muscle transfers due to the limited regenerative capacity and inability to reattach the rotator cuff to the humerus. Current surgical techniques primarily focus on mechanically reinforcing the tendon without promoting biological integration, leading to high re\u2010tear rates and functional limitations. This study aimed to evaluate OsTend, a biphasic osteotendinous scaffold designed to span the MIRC defect by bridging the muscle to the bone footprint. As such, OsTend is designed to be conducive to supporting tendon and bone regeneration while enabling muscle tissue ingrowth. OsTend consists of electrochemically aligned collagen threads braided into a three\u2010region scaffold: a proximal region for muscle integration, a midsection as a tendon regeneration template along with a polycaprolactone membrane as a suture rip\u2010stop, and a hydroxyapatite\u2010infused distal region to facilitate bone ingrowth. A total of 16 New Zealand White rabbits underwent unilateral infraspinatus tendon resection and repair with OsTend, followed by biomechanical testing, micro\u2010computed tomography, and histological analysis at 1 and 3\u2009months postimplantation. Results demonstrated a 65% increase in ultimate tensile strength from 1\u2009month (102.1\u2009\u00b1\u200921.5\u2009N) to 3\u2009months (167.9\u2009\u00b1\u200962.3\u2009N). Tendon retraction between 1\u2009month (7.47\u2009\u00b1\u20092.61\u2009mm) and 3\u2009months (6.77\u2009\u00b1\u20091.91\u2009mm) was &lt;\u20092\u2009mm during the study period. Bone volume fraction at 1\u2009month (24.80%\u2009\u00b1\u20098.30%) and 3\u2009months (21.52%\u2009\u00b1\u20094.97%) of the footprint reached approximately 75% of the intact bone (30%). Between 1 and 3\u2009months, the failure mode of repaired shoulders shifted from pullout at the enthesis (80% at 1\u2009month) to rupture at the mid\u2010substance (100% at 3\u2009months), indicating attainment of a functional integration between bone and scaffold over time. Histological analysis revealed collagen fiber alignment in the muscle and tendon regions and bone\u2010like tissue formation surrounding the hydroxyapatite\u2010infused region. These findings suggest that OsTend reestablishes tendon\u2013bone attachment with structural integrity; thus, this multiphasic biotextile platform holds the potential as an off\u2010the\u2010shelf biomaterial for treating massive irreparable rotator cuff tears.<\/jats:p>","DOI":"10.1002\/jbm.b.70154","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:39:48Z","timestamp":1790077188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Assessment of a Load\u2010Bearing Biphasic Osteotendinous Braided Collagen Scaffold for Reconstruction of Massive Irreparable Rotator Cuff Defects"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-1810","authenticated-orcid":false,"given":"Joohee","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-5070","authenticated-orcid":false,"given":"Phillip E.","family":"McClellan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1541-9618","authenticated-orcid":false,"given":"Anne D.","family":"Straits","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"CollaMedix Inc.  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9933-2111","authenticated-orcid":false,"given":"Alan","family":"Shepardson","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-8749","authenticated-orcid":false,"given":"Robert J.","family":"Gillespie","sequence":"additional","affiliation":[{"name":"CollaMedix Inc.  Cleveland Ohio USA"},{"name":"Department of Orthopaedic Surgery University Hospitals of Cleveland  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-4044","authenticated-orcid":false,"given":"James M.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Pathology Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Macromolecular Science and Engineering Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subba","family":"Shankar","sequence":"additional","affiliation":[{"name":"CollaMedix Inc.  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-3421","authenticated-orcid":false,"given":"Ozan","family":"Akkus","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University  Cleveland Ohio USA"},{"name":"CollaMedix Inc.  Cleveland Ohio USA"},{"name":"Department of Orthopaedic Surgery University Hospitals of Cleveland  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-4609","authenticated-orcid":false,"given":"Christian T.","family":"Denny","sequence":"additional","affiliation":[{"name":"CollaMedix Inc.  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-22-0015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01531"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.add8273"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-021-09714-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-017-0643-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-018-9465-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13175066"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-020-09674-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR-23-0027"},{"key":"e_1_2_11_11_1","article-title":"Treatment Options for Massive Rotator Cuff Tears: A Narrative Review","volume":"92","author":"Di Benedetto P.","year":"2021","journal-title":"Acta Biomedica Atenei Parmensis"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.156202"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2023.09.013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1115312"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomimetics8020246"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2015.08.008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-022-00220-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2022.05.025"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2555-3-29"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13040160"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34279"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465221097939"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912038"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227563"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12221-020-9771-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S59536"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201400828"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2012.06.012"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.103863"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(20000605)50:3<344::AID-JBM8>3.0.CO;2-D"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000001540"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2007.02.122"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546506297539"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2008.08.010"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2011.12.014"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2018.0383"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231180289"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-019-0160-3"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab48ca"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c00193"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201707306"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2024.100532"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2026.101097"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.12.024"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eats.2021.03.024"}],"container-title":["Journal of Biomedical Materials Research Part B: Applied Biomaterials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.b.70154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.b.70154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:24:08Z","timestamp":1790321048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.b.70154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jbm.b.70154"],"URL":"https:\/\/doi.org\/10.1002\/jbm.b.70154","archive":["Portico"],"relation":{},"ISSN":["1552-4973","1552-4981"],"issn-type":[{"value":"1552-4973","type":"print"},{"value":"1552-4981","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70154"}}