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To meet this challenge, we developed a porous carboxymethyl cellulose (CMC)\/alginate hydrogel loaded with Silver nanoparticles and a\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pistacia atlantica<\/jats:italic>\n                    <\/jats:styled-content>\n                    essential oil rich in\n                    <jats:italic>\u03b1\u2010pinene<\/jats:italic>\n                    . The hydrogel displayed remarkable swelling (up to 6362% over 72\u2009h) and changed the essential oil release from a rapid, volatile burst to a sustained, controlled profile (73% steady release over 96\u2009h). In\u00a0vitro tests revealed potent antibacterial activity against\n                    <jats:italic>\n                      Staphylococcus\n                      <jats:styled-content style=\"fixed-case\">aureus<\/jats:styled-content>\n                    <\/jats:italic>\n                    (MIC\u2009=\u2009650\u2009\u03bcg\/mL), significant antioxidant properties, and excellent cytocompatibility. Importantly, in\u00a0vivo studies in mice demonstrated a stage\u2010adaptive healing mechanism. Silver nanoparticles allowed rapid early infection control (47.4% wound closure by Day 4). Subsequently, the sustained release of the essential oil promoted robust tissue regeneration during the proliferative phase (82.6% closure by Day 7), driven by an enhanced TAC\u2010mediated antioxidant defense, reduced MDA levels, and accelerated hydroxyproline\u2010associated collagen synthesis. By Day 13, re\u2010epithelialization was near\u2010complete (93.6%), matching commercial controls. Ultimately, this synergistic integration of plant\u2010derived bioactives and metal antimicrobials presents a highly effective, stage\u2010specific platform for accelerated wound healing.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70157","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:03:21Z","timestamp":1790402601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\u2010Adaptive Polymeric Platforms: Design of an Alginate\/\n                    <scp>CMC<\/scp>\n                    Hydrogel Co\u2010Loaded With Silver Nanoparticles and\n                    <i>\u03b1\u2010Pinene<\/i>\n                    \u2010Rich Essential Oil for Wound Regeneration"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-757X","authenticated-orcid":false,"given":"Nasrin","family":"Kakaei","sequence":"first","affiliation":[{"name":"Cellular 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