{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:51:35Z","timestamp":1791175895303,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300422202"],"award-info":[{"award-number":["262300422202"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Postoperative intra\u2010abdominal adhesion remains a major limitation of intraperitoneal polypropylene (PP) mesh. We evaluated three poly(vinyl alcohol) (PVA)\u2010coated PP meshes\u2014PVA\u2013PP, rapamycin\u2010loaded liposome\u2010decorated PVA\u2013PP (RPM@LPS\/PVA\u2013PP), and the corresponding NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    \u2010containing formulation [RPM@LPS(NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    )\/PVA\u2013PP]\u2014in a four\u2010month exploratory laparoscopic Bama miniature\u2010pig study. Two pigs received all four formulations at anatomically separated, randomized abdominal\u2010wall sites, yielding 12 implantation sites in total and three site\u2010level observations per formulation. Gross adhesion, abdominal\u2010wall tissue\u2013mesh mechanics, histology, collagen composition, immunohistochemistry, and multiplex immunofluorescence were assessed. Unmodified PP produced dense visceral attachment at all three implantation sites (mean site\u2010level adhesion score, 4.00), whereas the mean scores for PVA\u2013PP, RPM@LPS\/PVA\u2013PP, and RPM@LPS(NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    )\/PVA\u2013PP were 0.50, 0.33, and 0.17, respectively. Adhesion area showed the same descriptive ordering. Mean abdominal\u2010wall tissue\u2013mesh lap\u2010shear and peel strengths were also lowest with RPM@LPS(NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    )\/PVA\u2013PP (0.0091\u2009MPa and 0.1766\u2009N\u2009mm\n                    <jats:sup>\u22121<\/jats:sup>\n                    , respectively) compared with PP (0.0500\u2009MPa and 0.7823\u2009N\u2009mm\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), indicating reduced host\u2010wall integration rather than direct mechanical confirmation of weaker visceral adhesion. Modified interfaces showed less dense fibrous tissue, lower total and Type I collagen, and a higher Type III collagen fraction. The mean Type I\/Type III collagen ratio decreased from 15.38 for PP to 2.27 for RPM@LPS(NaHCO\n                    <jats:sub>3<\/jats:sub>\n                    )\/PVA\u2013PP. Lower IL\u20106\u2010, TNF\u2010\u03b1\u2010, \u03b1\u2010SMA\u2010, CD31\u2010, CD68\u2010, and iNOS\u2010associated signals, together with a higher CD206\u2010positive\/CD68\u2010positive area ratio, accompanied these changes. These exploratory two\u2010animal findings show a descriptive association between the use of PVA\u2010coated PP meshes and reduced chronic visceral adhesion, while identifying host\u2010wall integration as a necessary safety consideration.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70162","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:11:19Z","timestamp":1791173479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four\u2010Month Evaluation of PVA\u2010Coated Polypropylene Meshes After Laparoscopic Intraperitoneal Implantation in an Exploratory Porcine Abdominal\u2010Wall Defect Model"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6928-9356","authenticated-orcid":false,"given":"Renjie","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"},{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Wei","sequence":"additional","affiliation":[{"name":"Henan Engineering Technology Research Center of Fiber Preparation and Modification, College of Material Engineering Henan University of Engineering  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"},{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2618-5616","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengya","family":"Jing","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhang","family":"Su","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zhongda Hospital, School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zhongda Hospital, School of Medicine Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-4334","authenticated-orcid":false,"given":"Tianzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"zrad080","DOI":"10.1093\/bjsopen\/zrad080","article-title":"Update of the International HerniaSurge Guidelines for Groin Hernia Management","volume":"7","author":"Stabilini C.","year":"2023","journal-title":"BJS Open"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00595-013-0591-8","article-title":"Adhesions After Abdominal Surgery: A Systematic Review of the Incidence, Distribution and Severity","volume":"44","author":"Okabayashi K.","year":"2014","journal-title":"Surgery Today"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/ams2.587","article-title":"Adhesive Small Bowel Obstruction \u2013 An Update","volume":"7","author":"Tong J. 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