{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:41:44Z","timestamp":1792212104168,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL172496"],"award-info":[{"award-number":["R01HL172496"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomed Mater Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    As hospital\u2010acquired infections and antibiotic and antifungal resistance increase, there is a need for constant innovation of novel antimicrobial solutions. To this end, the endogenous free\u2010radical gas nitric oxide has been explored, as nitric oxide kills bacteria effectively at low levels without producing significant cytotoxic effects. Biomaterials can be designed to release nitric oxide by incorporating nitric oxide donor molecules such as\n                    <jats:italic>S\u2010<\/jats:italic>\n                    nitrosothiols. Though nitric\u2010oxide\u2010releasing materials show excellent cytocompatibility and antibacterial activity, their efficacy against fungal species is limited. This work aims to combine nitric oxide release via an\n                    <jats:italic>S\u2010<\/jats:italic>\n                    nitrosothiol,\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitroso\n                    <jats:italic>\u2010N<\/jats:italic>\n                    \u2010acetylpenicillamine, with the release of a natural antifungal compound, piperine, from a commercially available biomedical polymer, CarboSil. In this work, a polymer platform was successfully developed that does not induce cytotoxicity while causing statistically significant reductions in the adhered and planktonic microbial loads of two bacterial strains and one fungal strain. This material is promising for preventing hospital\u2010acquired and biomaterial\u2010associated infections in short\u2010term applications.\n                  <\/jats:p>","DOI":"10.1002\/jbm.b.70168","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:58:27Z","timestamp":1792209507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Antifungal Activity of Nitric Oxide\u2010Releasing Polymers via the Incorporation of Piperine"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4373-8810","authenticated-orcid":false,"given":"Joseph H.","family":"Campbell","sequence":"first","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-5448","authenticated-orcid":false,"given":"Elizabeth J.","family":"Brisbois","sequence":"additional","affiliation":[{"name":"School of Chemical, Materials, and Biomedical Engineering University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010025\u201007611\u20107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70939"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00913"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm\u20102018\u20100275"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303259"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07484E"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2012.02.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/13500872\u2010145\u20107\u20101641"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00174"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c01330"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2007.10643575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362\u2010028x\u201069.2.369"},{"issue":"4","key":"e_1_2_10_14_1","first-page":"342","article-title":"Chemical Composition and Antimicrobial Activity of Essential Oil of \n                     Thymus vulgaris\n                   From Yemen","volume":"36","author":"Almaqtari M.","year":"2011","journal-title":"Turkish Journal of Biochemistry"},{"key":"e_1_2_10_15_1","first-page":"53","article-title":"Antimicrobial Activity of Some Spices Used in the Meat Industry","volume":"51","author":"A\u01e7ao\u01e7lu S.","year":"2007","journal-title":"Bulletin of the Veterinary Institute in Pulawy"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13121729"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0715323"},{"issue":"12","key":"e_1_2_10_18_1","first-page":"1134","article-title":"Antimicrobial Activity of Some Common Spices Against Certain Human Pathogens","volume":"3","author":"Joe M.","year":"2009","journal-title":"Journal of Medicinal Plant Research"},{"key":"e_1_2_10_19_1","first-page":"459","article-title":"Antimicrobial Effect of Seed Ethanolic Extract of Coriander","volume":"7","author":"Yakout S. 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