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Despite dysfunctional bone resorption, an augmented osteoclast differentiation was reported recently in ADOII patients. DNA sequencing analysis of the ADOII patient's <jats:italic>ClC\u20107<\/jats:italic> gene identified a known heterozygous mutation, c.643G&gt;A in exon 7, encoding p.Gly215Arg. In vitro osteoclast differentiation from the ADOII patient's peripheral blood mononuclear cells (PBMCs) increased compared with control despite their dysfunctional bone resorbing capacity. Osteoclasts from the ADOII patient's PBMCs and <jats:italic>ClC\u20107<\/jats:italic> knockdown bone marrow monocytes (BMMs) showed an enhanced Ser\u201071 phosphorylation of Rac1\/Cdc42 and increase of the microphthalmia\u2010associated transcription factor (MITF) and receptor activator of NF\u2010\u03baB (RANK) that can be responsible for the enhanced osteoclast differentiation. \u00a9 2018 The Authors. <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbm4.10070","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T19:25:06Z","timestamp":1530127506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhanced Activation of Rac1\/Cdc42 and MITF Leads to Augmented Osteoclastogenesis in Autosomal Dominant Osteopetrosis Type 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