{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:56:21Z","timestamp":1777431381011,"version":"3.51.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T00:00:00Z","timestamp":1547769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR041398, and AR061445"],"award-info":[{"award-number":["AR041398, and AR061445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201500001I"],"award-info":[{"award-number":["HHSN268201500001I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Osteoporosis treatment decisions are often based solely on BMD or on 10\u2010year fracture risk; little is known about factors increasing imminent fracture risk. Understanding factors contributing to imminent risk of fracture is potentially useful for personalizing therapy, especially among those at high risk. Our aim was to identify predictors of nonvertebral fracture for 1\u2010 and 2\u2010year periods in women at high risk for fracture. The Framingham Osteoporosis Study cohort included 1470 women (contributing 2778 observations), aged \u226565 years with BMD hip <jats:italic>T<\/jats:italic>\u2010score\u2009\u2264\u2009\u22121.0, or history of fragility fracture (irrespective of <jats:italic>T<\/jats:italic>\u2010score). Nonvertebral fractures were ascertained prospectively over 1 year and 2 years following a baseline BMD scan. Potential risk factors included age, anthropometric variables, comorbidities\/medical history, cognitive function, medications, history of fracture, self\u2010rated health, falls in the past year, smoking, physical performance, hip BMD <jats:italic>T<\/jats:italic>\u2010score, Activities of Daily Living (ADL) score, and caffeine and alcohol intakes. Predictive factors with <jats:italic>p<\/jats:italic> value\u2009\u2264\u20090.10 in bivariate Cox proportional hazards regression models were subsequently considered in multivariable models. Mean baseline age was 75 years (SD 6.0). During 1\u2010year follow\u2010up, 89 nonvertebral fractures occurred; during 2\u2010year follow\u2010up, 176 fractures occurred. Of the variables considered in the bivariate models, significant predictors of nonvertebral fractures included age, history of fracture, self\u2010rated health, falls in the prior year, BMD <jats:italic>T<\/jats:italic>\u2010score, ADL, renal disease, dementia, and current use of nitrates, beta\u2010blockers, calcium channel blockers, or antidepressants. In multivariable models, significant independent risk factors were history of fracture, self\u2010rated health, hip BMD <jats:italic>T<\/jats:italic>\u2010score, and use of nitrates. Significant 1\u2010year results were attenuated at the 2\u2010year follow\u2010up. In addition to the traditional factors of BMD and fracture history, self\u2010rated health and use of nitrates were independently associated with imminent risk of fracture in older, high\u2010risk women. These specific risk factors thus may be useful in identifying which women to target for therapy. \u00a92018 The Authors <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbm4.10129","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T18:58:38Z","timestamp":1543863518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Predictors of Imminent Risk of Nonvertebral Fracture in Older, High\u2010Risk Women: The Framingham Osteoporosis Study"],"prefix":"10.1093","volume":"3","author":[{"given":"Marian T","family":"Hannan","sequence":"first","affiliation":[{"name":"Institute for Aging Research Hebrew SeniorLife Department of Medicine Beth Israel Deaconess Medical Center, and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Weycker","sequence":"additional","affiliation":[{"name":"Policy Analysis Inc. (PAI) Brookline MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R","family":"McLean","sequence":"additional","affiliation":[{"name":"Corrona, LLC, Waltham, MA, USA, and Institute for Aging Research Hebrew SeniorLife Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Sahni","sequence":"additional","affiliation":[{"name":"Institute for Aging Research Hebrew SeniorLife Department of Medicine Beth Israel Deaconess Medical Center, and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Bornheimer","sequence":"additional","affiliation":[{"name":"Policy Analysis Inc. (PAI) Brookline MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Barron","sequence":"additional","affiliation":[{"name":"Amgen Thousand Oaks CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G","family":"Travison","sequence":"additional","affiliation":[{"name":"Institute for Aging Research Hebrew SeniorLife Department of Medicine Beth Israel Deaconess Medical Center, and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas P","family":"Kiel","sequence":"additional","affiliation":[{"name":"Institute for Aging Research Hebrew SeniorLife Department of Medicine Beth Israel Deaconess Medical Center, and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-1383(97)00144-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2393"},{"key":"e_1_2_8_4_1","first-page":"1","volume-title":"Osteoporosis: new perspectives on causes, prevention, and treatment","author":"Cooper C","year":"1996"},{"key":"e_1_2_8_5_1","unstructured":"National Osteoporosis Foundation editor. Clinician's guide to prevention and treatment of osteoporosis. Washington DC: National Osteoporosis Foundation;2013."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2011.05.010"},{"issue":"12","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1111\/jgs.13127","article-title":"Changes in bone mineral density may predict the risk of fracture differently in older adults according to fall history","volume":"62","author":"Berry SD","year":"2014","journal-title":"J Am Geriatr Soc"},{"key":"e_1_2_8_8_1","unstructured":"KanisJA W.H.O.Scientific Group. Assessment of osteoporosis at the primary health\u2010care level. In: W.H.O.Collaborative Centre for Metabolic Bone Diseases editor. Technical report. Sheffield UK: University of Sheffield;2007. p.2\u20134."},{"issue":"2","key":"e_1_2_8_9_1","first-page":"S224","article-title":"FRAX: facts and fantasy","volume":"16","author":"Gogate Y","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.404"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0280-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2794-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-57"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.9.874"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199409000-00004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00068-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291796003510"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.9.1160"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-008-0330-4"},{"issue":"12","key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1017\/S0033291713000342","article-title":"Use of self\u2010administered instruments to assess psychiatric disorders in older people: validity of the General Health Questionnaire, the Center for Epidemiologic Studies Depression Scale and the self\u2010completion version of the revised Clinical Interview Schedule","volume":"43","author":"Head J","year":"2013","journal-title":"Psychol Med"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.892537"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.4.710"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.20.2389"},{"issue":"1","key":"e_1_2_8_25_1","article-title":"Predictors of imminent fracture risk in Medicare\u2010enrolled men and women","volume":"31","author":"Yusuf A","year":"2016","journal-title":"J Bone Miner Res"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4103-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1989.10478873"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.09.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.06.019"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/30.suppl_4.25"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm4.10129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:54:13Z","timestamp":1710424453000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7478878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,18]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jbm4.10129"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10129","archive":["Portico"],"relation":{},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,18]]},"assertion":[{"value":"2018-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10129"}}