{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:14:08Z","timestamp":1778616848484,"version":"3.51.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP 26461470"],"award-info":[{"award-number":["JP 26461470"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23591444"],"award-info":[{"award-number":["23591444"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K09982"],"award-info":[{"award-number":["17K09982"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Specific major histocompatibility complex (MHC) class II genes result in a high susceptibility to rheumatoid arthritis (RA), with co\u2010stimulatory molecules working together with MHC class II during the progression of the disease. To elucidate the involvement of the B7.1 co\u2010stimulatory molecule in RA, we analyzed the phenotype of B7.1 transgenic (named D1BC) mice and the sequential differentiation of synovial fibroblasts (SFs) by studying the expression of chondrogenic and osteogenic lineage markers together with lineage tracing experiment using B7.1 transgene in vivo. The B7.1 transgene was driven by a collagen type II (CII) promoter and enhancer in the D1BC mouse. A low\u2010dose of bovine CII (bCII) was used to induce chronic articular inflammation with interstitial pneumonitis. Joint damage was analyzed by histopathological examination and computed tomography. <jats:italic>B7.1<\/jats:italic> was expressed in articular cartilage and SFs of D1BC mice. Chronic inflammatory arthritis in the bCII\u2010D1BC mouse shared common features with those found in patients with RA, such as pannus formation, bone destruction, osteoporosis, and joint ankylosis. A subpopulation of SFs (<jats:italic>Runx2<\/jats:italic><jats:sup>+<\/jats:sup>, <jats:italic>Sox9<\/jats:italic><jats:sup>+<\/jats:sup>, <jats:italic>Col10a1<\/jats:italic><jats:sup>+<\/jats:sup>, Osx<jats:sup>+<\/jats:sup>, and CX<jats:sup>\u2212<\/jats:sup>) in the pannus was classified as osteochondrogenic lineage rather than mesenchymal stromal lineage. These cells underwent differentiation into osteogenic lineage via hypertrophic chondrocytes at the end of the chronic phase. The ectopic expression of <jats:italic>B7.1<\/jats:italic> in chondrocytes and SFs leads to an increased susceptibility to chronic inflammatory arthritis and subsequent new bone formation, reminiscent of ankylosis. The regulation of cartilage remodeling in pannus tissue is an important consideration in the treatment of RA. \u00a9 2018 American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbm4.10132","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T18:07:59Z","timestamp":1544206079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Subpopulation of Synovial Fibroblasts Leads to Osteochondrogenesis in a Mouse Model of Chronic Inflammatory Rheumatoid Arthritis"],"prefix":"10.1093","volume":"3","author":[{"given":"Yoko","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Shizuoka Medical Center National Hospital Organization Suntou\u2010gun Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matija","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Departments of Medicine Microbiology and Immunology University of California San Francisco, San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grete","family":"McDevitt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and immunology Stanford University School of Medicine Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00321"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601135"},{"issue":"10","key":"e_1_2_7_5_1","first-page":"2094","article-title":"Synovium infiltrating T cells induce excessive synovial cell function through CD28\/B7 pathway in patients with rheumatoid arthritis","volume":"26","author":"Shimoyama Y","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200010)43:10<2160::AID-ANR3>3.0.CO;2-T"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"71","article-title":"Preferential expression of B7.2 (CD86), but not B7.1 (CD80), on B cells induced by CD40\/CD40L interaction is essential for anti\u2010DNA autoantibody production in patients with systemic lupus erythematosus","volume":"21","author":"Nagafuchi H","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199902)42:2<229::AID-ANR4>3.0.CO;2-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.5138"},{"issue":"3","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.4049\/jimmunol.153.3.1378","article-title":"Expression of functional B7 and CTLA4 on rheumatoid synovial T cells","volume":"153","author":"Verwilghen J","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3274"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519197113"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1156-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036786"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02120-05"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00358.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.03.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22288"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0572-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket205"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0504"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13699"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.12.005"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12203"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.111"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302703111"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3067"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515598135"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00122-0"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.11.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606450103"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440208"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.7.816"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30234"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-017-0534-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004820"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.3.493"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.079905"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002356"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm4.10132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002%2Fjbm4.10132","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/jbm4.10132\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:54:15Z","timestamp":1710424455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7478901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/jbm4.10132"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10132","archive":["Portico"],"relation":{},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10132"}}