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Although most data demonstrate an important function of this pathway in endochondral ossification and articular cartilage growth, conflicting results on its role in osteoarthritis have been reported. In some contexts, inactivation of EGFR signaling has been shown to protect joints from surgically induced osteoarthritis, whereas in others, similar manipulations worsened joint pathology. The current review summarizes recent studies of cartilage EGFR signaling in long bone development and diseases, provides potential explanations for the reported discrepancies, and suggests directions for future work to clarify the potential of this pathway as target for osteoarthritis treatment. \u00a9 2019 The Authors. <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbm4.10177","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T16:58:57Z","timestamp":1550077137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["EGFR Signaling: Friend or Foe for Cartilage?"],"prefix":"10.1093","volume":"3","author":[{"given":"Ling","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Beier","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology University of Western Ontario London Canada"},{"name":"Western Bone and Joint Institute University of Western Ontario London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83739-0"},{"issue":"10","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1016\/S0021-9258(19)85573-4","article-title":"Epidermal growth factor\u2010receptor\u2010protein kinase interactions. 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