{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:46:02Z","timestamp":1785350762078,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hypoparathyroidism patients suffer a variety of complaints often leading to reduced quality of life. Currently, no specific standard instrument exists to measure corresponding disease manifestations. We therefore aimed to develop a disease\u2010characteristic questionnaire for hypoparathyroid patients. We used an analytical\u2010empirical approach for questionnaire construction based on retrospective analysis of four well\u2010established but non\u2010disease\u2010specific questionnaires (Symptom Checklist 90, revised [SCL\u201090\u2010R]; Giessen Complaint List [GBB]; Short\u2010Form\u201036 Health Survey [SF\u201036]; von Zerssen Symptom List [B\u2010L Zerssen]) and two additional unpublished or local questionnaires (SHGdQ and GPQ) in a German hypoparathyroidism self\u2010help group (<jats:italic>n<\/jats:italic> =\u200960). Retrospective data were compared with corresponding general population norms. The new questionnaire was administered prospectively over 1 year to patients with postoperative hypoparathyroidism and two control groups to validate specificity. Exploratory factor analysis (EFA) and reliability testing were applied to identify relevant scales and reduce overlapping items. In the self\u2010help group, SCL\u201090\u2010R revealed elevated symptom load in four complaint areas (<jats:italic>p<\/jats:italic> =\u20090.003 to <jats:italic>p<\/jats:italic> &lt;\u20090.001). The SF\u201036 mental summary score (<jats:italic>p<\/jats:italic> &lt;\u20090.001) and further scales were lowered. In the GBB, four of five scales (<jats:italic>p<\/jats:italic> =\u20090.009 to <jats:italic>p<\/jats:italic> &lt;\u20090.001) were elevated. In the B\u2010L Zerssen, 6 of 24 items revealed complaint areas. Based on these findings, the new 40\u2010item \u201cHypoparathyroid Patient Questionnaire\u201d (HPQ 40) was developed, tested prospectively, and further analyzed. EFA revealed five scales (pain and cramps, gastrointestinal symptoms, depression and anxiety, neurovegetative symptoms, loss of vitality), all with Cronbach's alpha &gt;0.7. The questionnaire was revised accordingly and shortened to 28 questions to avoid redundancy. We present a new disease\u2010characteristic questionnaire for hypoparathyroidism patients. Prospective testing revealed five major complaint areas and promising psychometric properties. This questionnaire can be tested for usefulness in further clinical trials. \u00a9 2019 The Authors. <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. \u00a9 2019 The Authors. <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbm4.10245","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T17:51:18Z","timestamp":1571421078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The HPQ\u2014Development and First Administration of a Questionnaire for Hypoparathyroid Patients"],"prefix":"10.1093","volume":"4","author":[{"given":"Deborah","family":"Wilde","sequence":"first","affiliation":[{"name":"Clinic of Gastroenterology and Gastrointestinal Oncology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wilken","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Gastrointestinal Oncology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Stamm","sequence":"additional","affiliation":[{"name":"ENDOKRINOLOGIKUM Saarbr\u00fccken  Saarbr\u00fccken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Blaschke","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Gastrointestinal Oncology University Medical Center Goettingen  Goettingen Germany"},{"name":"MVZ Endokrinologikum Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Heppner","sequence":"additional","affiliation":[{"name":"MVZ Endokrinologikum Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira\u2010Lynn","family":"Chavanon","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Herrmann\u2010Lingen","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-8625","authenticated-orcid":false,"given":"Heide","family":"Siggelkow","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Gastrointestinal Oncology University Medical Center Goettingen  Goettingen Germany"},{"name":"MVZ Endokrinologikum Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1141-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1808"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0946"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460215"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2273"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2501"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1477"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2812"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2267"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3907"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13328.OR"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-012-0159-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1711"},{"key":"e_1_2_7_16_1","unstructured":"FrankeGH.Symptom\u2010Checklistevon L.R. 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