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This post hoc analysis evaluated the efficacy and safety of abaloparatide in patients with T2DM. The analysis included patients with T2DM from the <jats:bold>A<\/jats:bold>baloparatide <jats:bold>C<\/jats:bold>omparator <jats:bold>T<\/jats:bold>rial <jats:bold>I<\/jats:bold>n <jats:bold>V<\/jats:bold>ertebral <jats:bold>E<\/jats:bold>ndpoints (ACTIVE), a phase 3, double\u2010blind, randomized, placebo\u2010 and active\u2010controlled trial. In ACTIVE, participants were randomized 1:1:1 to daily s.c. injections of placebo, abaloparatide (80\u2009\u03bcg), or open\u2010label teriparatide (20\u2009\u03bcg) for 18\u2009months. A total of 198\u2009women with PMO and T2DM from 21 centers in 10 countries were identified from ACTIVE through review of their medical records. The main outcomes measured included effect of abaloparatide versus placebo on BMD and trabecular bone score (TBS), with secondary outcomes of fracture risk and safety, in patients from ACTIVE with T2DM. Significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) improvements in BMD at total hip (mean change 3.0% versus \u22120.4%), femoral neck (2.6% versus \u22120.2%), and lumbar spine (8.9% versus 1.3%) and TBS at lumbar spine (3.72% versus \u22120.56%) were observed with abaloparatide versus placebo at 18\u2009months. Fracture events were fewer with abaloparatide treatment in patients with T2DM, and differences were not significant between groups except nonvertebral fractures in the abaloparatide versus placebo groups (<jats:italic>p<\/jats:italic> = 0.04). Safety was consistent with the ACTIVE population. In conclusion, in women with PMO and T2DM, abaloparatide treatment resulted in significant improvements in BMD and TBS versus placebo, consistent with the overall ACTIVE population \u00a9 2020 The Authors. <jats:italic>JBMR Plus<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbm4.10346","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T17:15:31Z","timestamp":1580404531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Abaloparatide in Postmenopausal Women With Osteoporosis and Type 2 Diabetes: A Post Hoc Analysis of the ACTIVE Study"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-4006","authenticated-orcid":false,"given":"Ruban","family":"Dhaliwal","sequence":"first","affiliation":[{"name":"Metabolic Bone Disease Center State University of New York Upstate Medical University  Syracuse NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Hans","sequence":"additional","affiliation":[{"name":"Center of Bone Disease, Bones &amp; Joints Department Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Hattersley","sequence":"additional","affiliation":[{"name":"Clinical Development, Radius Health, Inc.  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