{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:31Z","timestamp":1772118691260,"version":"3.50.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR056246"],"award-info":[{"award-number":["R01AR056246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073607"],"award-info":[{"award-number":["R01AR073607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 2 diabetes mellitus (T2DM) is a multisystemic disease that afflicts more than 415 million people globally\u2014the incidence and prevalence of T2DM continues to rise. It is well\u2010known that T2DM has detrimental effects on bone quality that increase skeletal fragility, which predisposes subjects to an increased risk of fracture and fracture healing that results in non\u2010 or malunion. Diabetics have been found to have perturbations in metabolism, hormone production, and calcium homeostasis\u2014particularly PTH expression\u2014that contribute to the increased risk of fracture and decreased fracture healing. Given the perturbations in PTH expression and the establishment of hPTH (1\u201334) for use in age\u2010related osteoporosis, it was determined logical to attempt to ameliorate the bone phenotype found in T2DM using hPTH (1\u201334). Therefore, the present study had two aims: (i) to establish a suitable murine model of the skeletal fragility present in T2DM because no current consensus model exists; and (ii) to determine the effects of hPTH (1\u201334) on bone fractures in T2DM. The results of the present study suggest that the polygenic mouse of T2DM, TALLYHO\/JngJ, most accurately recapitulates the diabetic osteoporotic phenotype seen in humans and that the intermittent systemic administration of hPTH (1\u201334) increases fracture healing in T2DM murine models by increasing the proliferation of mesenchymal stem cells. \u00a9 2020 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10359","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T14:57:43Z","timestamp":1583852263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus"],"prefix":"10.1093","volume":"4","author":[{"given":"Kareme D","family":"Alder","sequence":"first","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew HA","family":"White","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon\u2010Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"},{"name":"Department of Life Science Chung\u2010Ang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JungHo","family":"Back","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuk\u2010Kwon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean V","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichen","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fancheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saelim","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-2441","authenticated-orcid":false,"given":"Francis Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthop\u00e6dics &amp; Rehabilitation Yale University, School of Medicine  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023060"},{"issue":"6","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/BF03549782","article-title":"Parathyroid hormone (1\u201034) and (1\u201084) stimulate cortical bone formation both from periosteum and endosteum","volume":"53","author":"Oxlund H","year":"1993","journal-title":"Calcif Tissue Int."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.03.017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0b013e31826f5b9e"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.6.960"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081207"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0097-y"},{"issue":"6","key":"e_1_2_7_12_1","first-page":"S164","article-title":"Osteoporosis and the burden of osteoporosis\u2010related fractures","volume":"17","author":"Dempster DW","year":"2011","journal-title":"Am J Manag Care."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1694-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.061113"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.1.24"},{"key":"e_1_2_7_16_1","volume-title":"National diabetes statistics report, 2017","author":"Centers for Disease Control and Prevention","year":"2017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0246-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.02.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.10.009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0960081"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33400"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1068"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90128-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071408"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24879"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S3940"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1002684"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081176"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21380"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2009.00128.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.7.1198"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.1.7139"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1909-1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051248"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.1.7248"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2537"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556002"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429772"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.10.058"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-6-30"},{"issue":"1","key":"e_1_2_7_41_1","first-page":"45","article-title":"Determinants of total body and regional bone mineral density in normal postmenopausal women\u2010a key role for fat mass","volume":"75","author":"Reid IR","year":"1992","journal-title":"J Clin Endocrinol Metabol."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.367"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(86)80017-1"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00046-9"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2006.04.013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-068-7_6"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-448-3_1"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1041"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2704-7"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2002.07.001"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328350a6e1"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0100-8"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0860"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.01.037"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0226"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1750405"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-015-0286-8"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035725"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105103441904"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.10.1846"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02115"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01443"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199909000-00033"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.11.2038"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0041-2"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2019.11.003"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00169-8"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.03.031"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.04.039"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00066-9"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008200009067660"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(68)90058-9"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199810001-00003"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3470-y"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.537"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198971050-00014"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm4.10359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:55:13Z","timestamp":1710410113000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7478990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/jbm4.10359"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10359","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10359\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10359\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10359\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10359\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10359\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"2020-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10359"}}