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Bone density testing showed borderline osteoporosis of the spine and osteopenia of the femur. Therapy with bisphosphonates and teriparatide failed to prevent further fractures. To our knowledge, this disorder has not been described previously. Investigations to date, including a genetic screen, have not revealed its cause. \u00a9 2020 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10365","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T08:19:15Z","timestamp":1587025155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Disorder of Osteoporosis, Osteonecrosis, and Metaphyseal Fracture"],"prefix":"10.1093","volume":"4","author":[{"given":"Hans\u2010Georg","family":"Zmierczak","sequence":"first","affiliation":[{"name":"Department of Endocrinology Ghent University Hospital  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Whanganui Hospital  Whanganui New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1371-1114","authenticated-orcid":false,"given":"Tim","family":"Cundy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medical and Health Sciences University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v6.i8.590"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"70","article-title":"Histomorphometric analysis of normal bone from the iliac crest","volume":"86","author":"Melsen F","year":"1978","journal-title":"Acta Pathol Microbiol Scand."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.253"},{"key":"e_1_2_7_5_1","unstructured":"Musculoskeletal Key. Fractures of the tibia\/fibula. 2016 [cited 2020 Apr 18] Available from:https:\/\/musculoskeletalkey.com\/fractures-of-the-tibiafibula\/"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160507"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200105000-00022"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm4.10365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:55:16Z","timestamp":1710410116000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7478944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,28]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/jbm4.10365"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10365","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10365\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10365\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10365\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10365\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10365\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10365\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,28]]},"assertion":[{"value":"2020-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10365"}}