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In this perspective, we provide a historical backdrop to this form of parathyroid disease and contend that this clinical presentation of excess parathyroid hormone, particularly in primary hyperparathyroidism, is still seen today. In view of its rarity and the way it typically presents, the diagnosis of metastatic cancer is often the first diagnostic impression. \u00a9 2020 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10403","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T19:41:13Z","timestamp":1596742873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Osteitis Fibrosa Cystica"],"prefix":"10.1093","volume":"4","author":[{"given":"Waldemar","family":"Misiorowski","sequence":"first","affiliation":[{"name":"Endocrinology Department, Centre of Postgraduate Medical Education Bielanski Hospital  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-2617","authenticated-orcid":false,"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology Division, College of Physicians and Surgeons Columbia University  New York 10032 NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1907828"},{"key":"e_1_2_5_3_1","volume-title":"Festschrift fur Rudolf Virchow","author":"Von Recklinghausen FD","year":"1891"},{"key":"e_1_2_5_4_1","volume-title":"Ueber einen fall von cystoider entartung des ganzen skelettes","author":"Endel G","year":"1864"},{"key":"e_1_2_5_5_1","first-page":"398","article-title":"Ueber ostitis deformans ohne ostoides gewebe","volume":"4","author":"Askanazy M","year":"1904","journal-title":"Arh Path\u2010Anat Inst T\u0171bingen."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-8-8-637"},{"key":"e_1_2_5_7_1","first-page":"2036","article-title":"Evaluation and management of primary hyperparathyroidism","volume":"81","author":"Silverberg SJ","year":"1966","journal-title":"J Clin Endocrinol Metab."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1414-2"},{"key":"e_1_2_5_9_1","unstructured":"BilezikianJP.Primary hyperparathyroidism.2017[cited 2017 Jan 15]. 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