{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:17:08Z","timestamp":1786378628642,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vitamin D deficiency is reported in individuals with primary hyperparathyroidism (PHP). However, decreased 25OHD may be attributed to enhanced conversion into 1,25\u2010hydroxyvitamin D [1,25(OH)D]. To examine vitamin D metabolism in individuals with PHP, serum calcium, PTH, 25OHD, and 1,25(OH)D levels were determined in 210 adults: 102 with PHP, 40 with normal 25OHD, and 68 with vitamin D deficiency. Concentrations were redetermined in 37 individuals with PHP following vitamin D supplementation and 43 patients postsurgery. Comparisons were conducted by Student's\n                    <jats:italic>t<\/jats:italic>\n                    test and ANOVA. Correlations were assessed between PTH and 25OHD, 1,25(OH)D, and 1,25(OH)D\/25OHD in individuals with PHP. Calcium, PTH, and 1,25(OH)D were higher (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.001) in individuals with PHP (11.4\u2009\u00b1\u20090.4, 116\u2009\u00b1\u200921, 79\u2009\u00b1\u20096) than in individuals with normal 25OHD (9.6\u2009\u00b1\u20090.2, 49\u2009\u00b1\u20095, 57\u2009\u00b1\u20096) and vitamin D deficiency (9.3\u2009\u00b1\u20090.2, 62\u2009\u00b1\u20096, 32\u2009\u00b1\u20094). Compared with individuals with normal 25OHD (47\u2009\u00b1\u20095), 25OHD was lower (18\u2009\u00b1\u20093), but not different from subjects with vitamin D deficiency (15\u2009\u00b1\u20092). In individuals with PHP, vitamin D2 supplementation induced rises in 1,25(OH)D and calcium without lowering PTH, whereas postsurgery, calcium, PTH, 25OHD, and 1,25(OH)D normalized. Finally, in individuals with PHP, significant correlations (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u20090.01) were documented between PTH and calcium (\n                    <jats:italic>r<\/jats:italic>\n                    =\u20090.74), 25OHD (\n                    <jats:italic>r<\/jats:italic>\n                    =\u2009\u22120.43), 1,25(OH)D (\n                    <jats:italic>r<\/jats:italic>\n                    =\u20090.52), and 1,25(OH)D\/25OHD (\n                    <jats:italic>r<\/jats:italic>\n                    =\u20090.46); and between 1,25(OH)D\/25OHD and calcium (\n                    <jats:italic>r<\/jats:italic>\n                    =\u20090.47). Subnormal 25OHD in most individuals with PHP may be attributed to enhanced conversion to 1,25(OH)D\u2014not \u201ctrue\u201d vitamin D deficiency\u2014although in some patients, both PHP and vitamin D deficiency coexisted. Moreover, vitamin D supplementation exaggerated hypercalcemia in individuals with PHP. \u00a9 2020 The Author.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10415","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T17:20:12Z","timestamp":1600881612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Low 25\u2010Hydroxyvitamin D in Primary Hyperparathyroidism: Enhanced Conversion Into 1,25\u2010Hydroxyvitamin D May Not Be \u201cTrue\u201d Deficiency"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-6065","authenticated-orcid":false,"given":"Udaya M","family":"Kabadi","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Broadlawns Medical Center, Des Moines, IA University of Iowa  Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0056-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3978"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3199-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4218"},{"issue":"4","key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/0004563214564400","article-title":"Impact of vitamin D replacement in patients with normocalcemic and hypercalcemic primary hyperparathyroidism and coexisting vitamin D deficiency","volume":"52","author":"Das G","year":"2015","journal-title":"Ann Clin Biochem."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3637-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP161434.OR"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0974-x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0931-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3918-2"},{"issue":"2","key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/hcx200","article-title":"The impact of vitamin D status and parameters of calcium metabolism in patients with primary hyperparathyroidism","volume":"111","author":"Tripto\u2010Shkolnik L","year":"2018","journal-title":"QJM."},{"issue":"1","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1542\/peds.68.1.109","article-title":"Effect of parathyroid hormone on vitamin D metabolism in osteopetrosis","volume":"68","author":"Aarskog D","year":"1981","journal-title":"Pediatrics."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000486060"},{"issue":"8","key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1056\/NEJM198002213020801","article-title":"The importance of circulating 1,25 dihydroxy vitamin D in the pathogenesis of hypercalciuria and renal stone formation in primary hyperparathyroidism","volume":"302","author":"Broadus AE","year":"1980","journal-title":"N Engl J Med."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90346-F"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1772"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"issue":"3","key":"e_1_2_6_20_1","first-page":"1","article-title":"Improvement in bone density with calcitriol substitution for cholecalciferol in refractory osteoporosis induced by prednisone","volume":"2","author":"Salina E","year":"2018","journal-title":"Endocrinol Diab Metab J"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12398"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00705"},{"key":"e_1_2_6_23_1","unstructured":"KabadiUM.Non suppressible PTH with vitamin D supplementation in normocalcemic primary hyperparathyroidism and low 25 OH vitamin D. Poster presented at: 97th Annual Meeting and Expo of the Endocrine Society; 2015 March 5\u20138; San Diego CA."},{"issue":"5","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jcem-56-5-953","article-title":"A detailed evaluation of oral phosphate therapy in selected patients with primary hyperparathyroidism","volume":"56","author":"Broadus AE","year":"1983","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"e_1_2_6_25_1","first-page":"S131","article-title":"Medical management of asymptomatic primary hyperparathyroidism","volume":"6","author":"Shane E","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"3","key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0889-8529(05)70149-3","article-title":"Medical approaches to primary hyperparathyroidism","volume":"29","author":"Strewler GJ","year":"2004","journal-title":"Endocrinol Metab Clin North Am."}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:55:34Z","timestamp":1710410134000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7486259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/jbm4.10415"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10415","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10415\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10415\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10415\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10415\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10415\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,18]]},"assertion":[{"value":"2020-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10415"}}