{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:12Z","timestamp":1772118672094,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated the expression profile of selected microRNAs (miRs) in serum and tissue samples from patients with sporadic parathyroid adenomas (sPAs). This was a prospective, controlled cohort study. Forty patients with sPAs who had undergone parathyroidectomy (PTX) were included. MiR extraction was performed from (i) 40 formalin\u2010fixed paraffin\u2010embedded samples (FFPEs) of sPAs, (ii) 10 FFPEs of normal parathyroid tissue (NPT), (iii) serum samples of the 40 patients with sPAs (t1 = baseline; t2 = 2\u2009months post\u2010PTX), and (vi) serum samples of 10 healthy individuals (controls; t1 = baseline and t2 = 2\u2009months later). Ten miRs were selected based on their interaction with genes related to parathyroid tumorigenesis (miR\u201017\u20105p, miR\u201024\u20103p, miR\u201029b\u20103p, miR\u201031\u20105p, miR\u2010135b\u20105p, miR\u2010186\u20105p, miR\u2010195\u20105p, miR\u2010330\u20103p, miR\u2010483\u20103p, and miR\u2010877\u20105p). At tissue level, the relative expression of miR\u201017\u20105p, miR\u201031\u20105p, miR\u2010135b\u20105p, miR\u2010186\u20105p, and miR\u2010330\u20103p was significantly decreased (fold change [FC]: 0.17, FC: 0.03, FC: 0.01, FC: 0.10, FC: 0.10, respectively; all\n                    <jats:italic>p<\/jats:italic>\n                    values &lt;0.001), and the expression of miR\u201024\u20103p and miR\u201029b\u20103p was significantly increased (FC: 12.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; FC: 18.5,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.011, respectively) in sPA compared with NPT samples. The relative expression of miR\u2010135b\u20105p was also significantly decreased in the serum samples of patients compared with controls (FC: 0.7,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.035). No significant differences were found in the serum samples of patients before and after PTX. MiRs that regulate genes linked to parathyroid tumors such as menin 1 (miR\u201024\u20103p, miR\u201029b\u20103p), cyclin D1 (miR\u201017\u20105p), calcium sensing receptor (miR\u201031\u20105p, miR\u2010135b\u20105p), cyclin\u2010dependent kinase inhibitors (miR\u2010186\u20105p), and \u03b2\u2010catenin (miR\u2010330\u20103p) were significantly deregulated in sPAs compared with NPT samples, suggesting a role for epigenetic changes in parathyroid tumorigenesis. \u00a9 2020 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10431","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T14:54:54Z","timestamp":1605192894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circulating and Tissue Expression Profile of\n                    <scp>MicroRNAs<\/scp>\n                    in Primary Hyperparathyroidism Caused by Sporadic Parathyroid Adenomas"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-3692","authenticated-orcid":false,"given":"Maria P","family":"Yavropoulou","sequence":"first","affiliation":[{"name":"Endocrinology Unit, 1st Department of Propaedeutic and Internal Medicine, Medical School National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Medical Research 251 Hellenic Air Force &amp; VA General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalliopi","family":"Pazaitou\u2010Panayiotou","sequence":"additional","affiliation":[{"name":"Interbalkan Medical Center  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G","family":"Yovos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Poulios","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-6296","authenticated-orcid":false,"given":"Athanasios D","family":"Anastasilakis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology 424 General Military Hospital  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Vlachodimitropoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Medicine and Toxicology, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriakos","family":"Vamvakidis","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Henry Dunant Hospital Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Tsave","sequence":"additional","affiliation":[{"name":"Department of Medical Research 251 Hellenic Air Force &amp; VA General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Chrisafi","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Daskalaki","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine Aristotle University of Thessaloniki  Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3231-3357","authenticated-orcid":false,"given":"Polyzois","family":"Makras","sequence":"additional","affiliation":[{"name":"Department of Medical Research 251 Hellenic Air Force &amp; VA General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0344"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090304"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2017.14.1.060"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-18-0304"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911423096"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09267"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149460"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-09-0134"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.10.035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-274191"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0204"},{"issue":"4","key":"e_1_2_9_14_1","first-page":"1743","article-title":"Analysis of differentially expressed microRNAs in MEN1 parathyroid adenomas","volume":"9","author":"Luzi E","year":"2017","journal-title":"Am J Transl Res."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.12.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22844-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16113-x"},{"issue":"1","key":"e_1_2_9_19_1","first-page":"72","article-title":"Circulating microRNAs in the early prediction of disease recurrence in primary breast cancer breast","volume":"20","author":"Papadaki C","year":"2018","journal-title":"Cancer Res."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1723"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197303)31:3<600::AID-CNCR2820310316>3.0.CO;2-0"},{"issue":"1","key":"e_1_2_9_22_1","article-title":"A role for circular non\u2010coding RNAs in the pathogenesis of sporadic parathyroid adenomas and the impact of gender\u2010specific epigenetic regulation","volume":"8","author":"Yavropoulou MP","year":"2018","journal-title":"Cell."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-010-9121-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3288-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000378"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1359-7"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1681"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.204131"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6754"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-11-0189"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1475-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2175"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804549105"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29681"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109428"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:55:41Z","timestamp":1710410141000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7499094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/jbm4.10431"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10431","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10431\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10431\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"2020-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10431"}}