{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:11:36Z","timestamp":1792987896971,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["072609"],"award-info":[{"award-number":["072609"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Micro\u2010computed tomography is a critical assessment tool for bone\u2010related preclinical research, especially in murine models. To expedite the scanning process, researchers often image multiple bones simultaneously; however, it is unknown if this impacts scan quality and alters the ability to detect differences between experimental groups. The purpose of this study was to assess the effect of multibone scanning on detecting disease\u2010induced changes in bone microarchitecture and mineral density by group scanning two murine models with known skeletal defects: the\n                    <jats:italic>Col1a2<\/jats:italic>\n                    <jats:sup>G610C\/+<\/jats:sup>\n                    model of osteogenesis imperfecta and an adenine\u2010induced model of chronic kidney disease. Adult male femurs were scanned individually and in random groups of three and eight in a Bruker Skyscan 1172 and 1176, respectively, then assessed for standard trabecular and cortical bone measures. Although scanning methodology altered raw values, with trabecular microarchitecture values more affected than cortical properties, a disease phenotype was still detectable in both group and solo scans. However, tissue mineral density in both trabecular and cortical bone was significantly impacted by group versus solo scanning. Researchers may be able to use small groupings in a single \u03bcCT scan to expedite preclinical analyses when the overall bone phenotype is large to decrease costs and increase speed of discoveries; however the details of scanning (single or group) should always be reported. \u00a9 2021 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10473","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T01:47:55Z","timestamp":1612921675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Effect of Single Versus Group\n                    <scp>\u03bcCT<\/scp>\n                    on the Detection of Trabecular and Cortical Disease Phenotypes in Mouse Bones"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-6546","authenticated-orcid":false,"given":"Rachel","family":"Kohler","sequence":"first","affiliation":[{"name":"Weldon School of Biomedical Engineering department of Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carli A","family":"Tastad","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Indiana University Purdue University of Indianapolis  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J","family":"Stacy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Indiana University Purdue University of Indianapolis  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Swallow","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne E","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-9004","authenticated-orcid":false,"given":"Matthew R","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Indiana University Purdue University of Indianapolis  Indianapolis IN USA"},{"name":"Department of Anatomy and Cell Biology Indiana University School of Medicine  Indianapolis IN USA"},{"name":"Division of Nephrology, Department of Medicine Indiana University School of Medicine  Indianapolis IN USA"},{"name":"Roudebush Veterans Administration Medical Center  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-8058","authenticated-orcid":false,"given":"Joseph M","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Indiana University Purdue University of Indianapolis  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2478\/gsr-2018-0006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2807"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03014-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.08.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050307"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2019.100195"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070507"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1282"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-019-00642-w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.06.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24177"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130504"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.02.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"42","article-title":"Comparison between quantitative x\u2010ray imaging, dual energy x\u2010ray absorptiometry and microCT in the assessment of bone mineral density in disuse\u2010induced bone loss","volume":"15","author":"Mabilleau G","year":"2015","journal-title":"J Musculoskelet Neuronal Interact."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.04.021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.05.013"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:56:00Z","timestamp":1710410160000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7499124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jbm4.10473"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10473","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10473\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10473\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"2020-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10473"}}