{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:39:21Z","timestamp":1793975961428,"version":"4.8.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic hypoparathyroidism (HypoPT) is a common complication after total thyroidectomy and it impacts affected patients' quality of life (QoL). This study aimed to assess the QoL in patients with chronic HypoPT independently from their concurrent hypothyroidism and other comorbidities. For this purpose a follow\u2010up study was performed, including 14 patients who developed chronic HypoPT after total thyroidectomy and 28 age\u2010 and sex\u2010matched patients who had intact parathyroid function after total thyroidectomy. We used the RAND Short Form 36 Health Survey (SF\u201036) to compare the QoL between patients with or without chronic HypoPT. Chronic HypoPT patients had lower QoL scores in all domains of the RAND\u2010SF\u201036 questionnaire and significant impairment in six of eight domains after adjustment for relevant confounders. They were more often operated because of a toxic diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    = .01), often being Graves disease. Additionally adjusting for surgical indications resulted in three of eight domains being significant affected. Chronic HypoPT is associated with significantly impairment of QoL, independently of the concurrent disease of hypothyroidism, comorbidities, and prospective values of TSH and serum (se)\u2010ionized\u2010Ca\n                    <jats:sup>++<\/jats:sup>\n                    . There is a need for more focus and better treatment of patients experiencing chronic HypoPT after surgery. \u00a9 2021 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10479","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T16:18:44Z","timestamp":1613665124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Postoperative Chronic Hypoparathyroidism and Quality of Life After Total Thyroidectomy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-6129","authenticated-orcid":false,"given":"Camilla Uhre","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital (ZUH)  K\u00f8ge Denmark"},{"name":"Department of Medical Endocrinology Zealand University Hospital (ZUH)  K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-3518","authenticated-orcid":false,"given":"Preben","family":"Hom\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Maxillofacial Surgery Zealand University Hospital (ZUH)  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Zealand University Hospital (ZUH)  K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-8552","authenticated-orcid":false,"given":"Mette Friberg","family":"Hitz","sequence":"additional","affiliation":[{"name":"Department of Medical Endocrinology Zealand University Hospital (ZUH)  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9384"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000470840"},{"issue":"11","key":"e_1_2_11_5_1","first-page":"A5156","article-title":"Long\u2010term outcomes after total thyroidectomy","volume":"62","author":"Jensen 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