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However, recent advances in HRpQCT offer methods to accurately monitor microstructural bone remodeling throughout the healing process. In this study, local bone formation and resorption were investigated during the first year post fracture in both the fractured (n\u00a0=\u00a022) and contralateral (n\u00a0=\u00a019) radii of 34 conservatively treated patients (24 female, 10 male) who presented with a unilateral radius fracture at the Innsbruck University Hospital, Austria. HRpQCT images and clinical metrics were acquired at six time points for each patient. The standard HRpQCT image acquisition was captured for all radii, with additional distal and proximal image acquisitions for the fractured radii. Measured radial bone densities were isolated with a voxel\u2010based mask and images were rigidly registered to images from the previous imaging session using a pyramid\u2010based approach. From the registered images, bone formation and resorption volume fractions were quantified for multiple density\u2010based thresholds and compared between the fractured and contralateral radius and relative to demographics, bone morphometrics, and fracture metrics using regression. Compared with the contralateral radius, both bone formation and resorption were significantly increased in the fractured radius throughout the study for nearly all evaluated thresholds. Higher density cortical bone formation continually increased throughout the duration of the study and was significantly greater than resorption during late\u2010stage healing in both the fractured and intact regions of the radius. With the small and diverse study population, only weak relationships between fracture remodeling and patient\u2010specific parameters were unveiled. However this study provides methods for the analysis of local bone remodeling during fracture healing and highlights relevant considerations for future studies, specifically that remodeling postfracture is likely to continue beyond 12\u2010months postfracture. \u00a9 2021 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10493","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T12:29:30Z","timestamp":1616416170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Formation Dominates Resorption With Increasing Mineralized Density and Time Postfracture in Cortical but Not Trabecular Bone: A Longitudinal\n                    <scp>HRpQCT<\/scp>\n                    Imaging Study in the Distal Radius"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9930-2604","authenticated-orcid":false,"given":"Penny R","family":"Atkins","sequence":"first","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich  Zurich Switzerland"},{"name":"Department of Osteoporosis Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Stock","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-4383","authenticated-orcid":false,"given":"Nicholas","family":"Ohs","sequence":"additional","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-878X","authenticated-orcid":false,"given":"Caitlyn J","family":"Collins","sequence":"additional","affiliation":[{"name":"Institute for Biomechanics, ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Horling","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Benedikt","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Degenhart","sequence":"additional","affiliation":[{"name":"Department of Radiology Medical University Innsbruck  Innsbruck 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