{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:15:06Z","timestamp":1793459706932,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Severe osteoporotic fractures (hip, proximal humerus, pelvic, vertebral and multiple rib fractures) carry an increased risk of mortality. This retrospective cohort study in the French national healthcare database aimed to estimate refracture and mortality rates after severe osteoporotic fractures at different sites, and to identify mortality\u2010related variables. A total of 356,895 patients hospitalized for severe osteoporotic fracture between 2009 and 2014 inclusive were analyzed. The cohort was followed for 2 to 8\u2009years up to the study end or until the patient died. Data were extracted on subsequent hospitalizations, refracture events, treatments, comorbidities of interest and survival. Time to refracture and survival were described using Kaplan\u2010Meier analysis by site of fracture and overall. Mortality risk factors were identified using a Cox model. Hip fractures accounted for 60.4% of the sample (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0215,672). In the 12\u2009months following fracture, 58,220 patients (16.7%) received a specific osteoporosis treatment, of whom 21,228 were previously treatment\u2010na\u00efve. The 12\u2010month refracture rate was 6.3% (95% confidence interval [CI], 6.2%\u20136.3%), ranging from 4.0% (95% CI, 3.7%\u20134.3%) for multiple rib fractures to 7.8% (95% CI, 7.5%\u20138.1%) for pelvic fractures. Twelve\u2010month all\u2010cause mortality was 12.8% (95% CI, 12.7%\u201312.9%), ranging from 5.0% (95% CI, 4.7%\u20135.2%) for vertebral fractures to 16.6% (95% CI, 16.4%\u201316.7%) for hip fractures. Osteoporosis\u2010related mortality risk factors included fracture site, previous osteoporotic fracture (hazard ratio 1.21; 95% CI, 1.18\u20131.23), hip refracture (1.74; 95% CI, 1.71\u20131.77), and no prior osteoporosis treatment (1.24; 95% CI, 1.22\u20131.26). Comorbid cancer (3.15; 95% CI, 3.09\u20133.21) and liver disease (2.54; 95% CI, 2.40\u20132.68) were also strongly associated with mortality. In conclusion, severe osteoporotic fractures, including certain non\u2010hip nonvertebral fractures, carry a high burden in terms of mortality and refracture risk. However, most patients received no anti\u2010osteoporotic treatment. The findings emphasize the importance of better management of patients with severe fractures, and of developing effective strategies to reduce fracture risk in patients with osteoporosis. \u00a9 2021 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10507","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T18:23:39Z","timestamp":1620325419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Refracture and mortality following hospitalization for severe osteoporotic fractures: The Fractos Study"],"prefix":"10.1093","volume":"5","author":[{"given":"Christian","family":"Roux","sequence":"first","affiliation":[{"name":"Department of Rheumatology Cochin Hospital, Assistance Publique \u2010 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