{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:01:15Z","timestamp":1793106075834,"version":"4.5.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quality of life (QoL) is impaired in patients with chronic hypoparathyroidism (HypoPT). With a recently developed specific patient questionnaire, the 28\u2010item Hypoparathyroid Patient Questionnaire (HPQ 28), we were able to demonstrate an effect of laboratory parameters on symptoms and complaints identified by scales and items of the HPQ 28. Here, we evaluated the effect of conventional treatment modalities on QoL using this specific questionnaire. In this cross\u2010sectional study, we included 49 HypoPT (41 female and 8 male) patients. Laboratory values of total serum calcium, magnesium, phosphate, calcium\u2010phosphate product (CPP), and 24\u2010hour urine for calcium and phosphate were analyzed. Patients completed the HPQ 28 questionnaire during the corresponding visit. Mean age was 57.3\u2009\u00b1\u200910.5\u2009years and duration of disease 12.6\u2009\u00b1\u20099.8\u2009years. Most patients (86%,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200942) were treated with the active vitamin D analogs calcitriol, alfacalcidol, or dihydrotachysterol (DHT). The use of calcium and magnesium supplements influenced scales on HPQ 28 in a dose\u2010dependent manner. We detected a dose\u2010dependent increase on the HPQ 28 scales \u201cdepression and anxiety\u201d and \u201cpain and cramps,\u201d and the item \u201cnumbness and tingling\u201d related to calcitriol. This effect was independent of gender, age, underlying disease, kind of surgery, serum 25\u2010hydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    , calcium, or phosphate values. This study presents the first data on specific symptoms of HypoPT patients dependent on different treatment modalities. Our data suggest that in part the reduced QoL in these patients might be caused by conventional treatment. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10586","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T04:35:06Z","timestamp":1638160506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Influence of Conventional Treatment on Symptoms and Complaints in Patients With Chronic Postsurgical Hypoparathyroidism"],"prefix":"10.1093","volume":"6","author":[{"given":"Bettina","family":"Stamm","sequence":"first","affiliation":[{"name":"Endokrinologikum Saarbruecken  Saarbruecken Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Blaschke","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Wilken","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Wilde","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Heppner","sequence":"additional","affiliation":[{"name":"MVZ Endokrinologikum Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Herrmann\u2010Lingen","sequence":"additional","affiliation":[{"name":"Department for Psychosomatic Medicine and Psychotherapy University Medical Center Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-8625","authenticated-orcid":false,"given":"Heide","family":"Siggelkow","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Gastrointestinal Oncology and Endocrinology University Medical Center Goettingen  Goettingen Germany"},{"name":"MVZ Endokrinologikum Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3907"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1808"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1477"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2812"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0857-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460215"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13593"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14128"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.55"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.09.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S179310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-019-00388-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10245"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10368"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0803050"},{"issue":"9","key":"e_1_2_8_19_1","first-page":"652","article-title":"Gastrointestinal tract as a side\u2010effect target of medications","volume":"73","author":"Domagala\u2010Rodacka R","year":"2016","journal-title":"Przegl Lek"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1484"}],"container-title":["JBMR 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