{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:02:26Z","timestamp":1782234146065,"version":"3.54.5"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20261"],"award-info":[{"award-number":["20261"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","award":["16ICH02"],"award-info":[{"award-number":["16ICH02"]}],"id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Children with osteogenesis imperfecta (OI) are commonly treated with bisphosphonates. We investigated the skeletal response to mechanical stimulation in children with OI before and after bisphosphonate treatment. Twelve children with OI, na\u00efve to bisphosphonate treatment, stood on a high\u2010frequency (30\u2009Hz), low\u2010amplitude (50 to 200\u2009\u03bc) vibrating platform (Marodyne LivMD) for 10\u00a0minutes daily (2.5\u2009minutes\u2009\u00d7\u20094 with interspersed 1\u2010minute rest periods) for 7\u2009days (whole body vibration [WBV] 1; day (D) 1\u20137), followed successively by 5\u2009weeks' monitoring without intervention, 6\u2009weeks' risedronate treatment, 1\u2009week of WBV (WBV2; D85\u201391), and 1\u2009week without intervention (D92\u201398). Procollagen type I N\u2010terminal propeptide (P1NP), bone\u2010specific alkaline phosphatase (BSALP), and carboxy\u2010terminal telopeptide of type I collagen cross\u2010link (CTX) were measured at baseline and intervals bracketing periods of vibration and risedronate treatment. Both P1NP and CTX rose to D8 (18.4%, 13.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05, respectively), plateaued, then rose again at D43 (19.8%, 19.2%, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 versus baseline). At D85 (after risedronate) both P1NP and CTX had fallen to pre\u2010WBV1 levels. A significantly smaller increase in P1NP was found after WBV2 (D85\u201391) at D92 (3.5%, 9.2%, respectively) and D99 versus after WBV1 (both\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). BSALP changed little after WBV1, fell during risedronate, and rose toward baseline after WBV2. We thus showed that WBV increased bone formation and resorption; that increase was attenuated after risedronate. The early increase in P1NP and CTX (D8) after WBV1 suggests increased osteoid formation within existing remodeling units but not increased mineralization. Later increases in P1NP\/CTX (D42) suggest increased remodeling cycle initiation after WBV. Risedronate suppressed both biomarkers. The lower increase in P1NP\/CTX after WBV2 suggests limited capacity to increase osteoid formation from existing \u201cearly stage\u201d osteoblasts and a possible \u201changover\u201d effect of risedronate on remodeling activation. These results provide insights into both the response to WBV, ie, mechanical stimulation, and the effect of antiresorptive therapy in children with OI. \u00a9 2021 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10592","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T10:38:41Z","timestamp":1639391921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bisphosphonate Treatment Alters the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta: A Pilot Study"],"prefix":"10.1093","volume":"6","author":[{"given":"Siva","family":"Sithambaran","sequence":"first","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Harrison","sequence":"additional","affiliation":[{"name":"Sheffield Children's NHS FT  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatha","family":"Gopal\u2010Kothandapandi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Rigby","sequence":"additional","affiliation":[{"name":"University of Hull  Hull UK"},{"name":"Hull York Medical School  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-8546","authenticated-orcid":false,"given":"Nick","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield  Sheffield UK"},{"name":"Sheffield Children's NHS FT  Sheffield 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