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To address this question, we established a mouse model in which all molars were extracted from the maxillary right quadrant in prepubertal, 3\u2010week\u2010old mice and analyzed morphological, tissue, cellular, and molecular changes in the mandible and condyle 3\u2009weeks later. Unilateral loss of maxillary molars led to significant, robust, bilateral changes, primarily in condylar morphology, including anteroposterior narrowing of the condylar head and neck and increased convexity at the condylar surface, as determined by geometric morphometric analysis. Furthermore, both condyles in experimental mice exhibited a degenerative phenotype, which included decreased bone volume and increased mineral density near the condylar head surface compared to control mice. Changes in condylar morphology and mineralized tissue composition were associated with alterations in the cellular architecture of the mandibular condylar cartilage, including increased expression of markers for mature (\n                    <jats:italic>Col2a1<\/jats:italic>\n                    ) and hypertrophic (\n                    <jats:italic>Col10a1<\/jats:italic>\n                    ) chondrocytes, suggesting a shift toward differentiating chondrocytes. Our results show significant bilateral condylar morphological changes, alterations in tissue composition, cellular organization, and molecular expression, as well as degenerative disease, in response to the unilateral loss of teeth. Our study provides a relatively simple, tractable mouse tooth extraction system that will be of utility in uncovering the cellular and molecular mechanisms of condylar and mandibular adaptation in response to altered occlusion. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10638","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T04:44:50Z","timestamp":1653799490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unilateral Loss of Maxillary Molars in Young Mice Leads to Bilateral Condylar Adaptation and Degenerative Disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Christopher Phillip","family":"Chen","sequence":"first","affiliation":[{"name":"Division of 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