{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:13:44Z","timestamp":1790626424728,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    X\u2010linked hypophosphatemia (XLH) is a rare genetic disorder that disrupts skeletal and dental mineralization. In addition to rickets in children, XLH patients also have frequent spontaneous dental abscesses that increase the risk of tooth loss and may lead to facial cellulitis. Hypomineralized and hypoplastic dentin is the main driver of these infections. Conventional treatment (CT) of XLH improves this tissue defect and reduces the occurrence of dental abscesses. Burosumab is a recent treatment for XLH that targets excess circulating fibroblast growth factor 23 (FGF23), and its benefits on rickets have been demonstrated. It is not yet known whether burosumab improves dental manifestations of XLH. The main objective of our study was to compare the incidence of dental abscesses with XLH treated with either CT or burosumab. In this monocentric retrospective study, we measured and compared the incidence of dental abscess in children with XLH treated with either CT or burosumab, followed at our dental center for at least 1\u2009year. The primary endpoint was the number of dental abscesses per month of dental follow\u2010up. A total of 71 children were included in the study, with a mean \u00b1 standard deviation (SD) age at the start of dental follow\u2010up of 7.86 \u00b1\u20093.76. Thirty\u2010eight children were treated with CT (53.5%) and 33 with burosumab (46.5%). All children treated with burosumab had previously been treated with CT. The mean number of dental abscesses per month of dental follow\u2010up was significantly reduced in the burosumab group compared with the CT group (0.01 versus 0.04;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.04). Burosumab treatment appears to be associated with a reduction in the number of dental abscesses in XLH children, compared with CT. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10672","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T10:24:34Z","timestamp":1659003874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Burosumab and Dental Abscesses in Children With\n                    <scp>X\u2010Linked<\/scp>\n                    Hypophosphatemia"],"prefix":"10.1093","volume":"6","author":[{"given":"Margaux","family":"Gadion","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, F\u00e9d\u00e9ration hospitalo\u2010universitaire DDS\u2010net, European reference network BOND, Department of Dental Medicine Bretonneau Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Herv\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, F\u00e9d\u00e9ration hospitalo\u2010universitaire DDS\u2010net, European reference network BOND, Department of Dental Medicine Bretonneau Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Herrou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, European reference network BOND, Department of Rheumatology Cochin Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Rothenbuhler","sequence":"additional","affiliation":[{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, Endo\u2010European reference network and European reference network BOND, Department of Endocrinology and Diabetology for Children Bic\u00eatre Paris Saclay Hospital  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Smail\u2010Faugeron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, F\u00e9d\u00e9ration hospitalo\u2010universitaire DDS\u2010net, European reference network BOND, Department of Dental Medicine Bretonneau Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Courson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, F\u00e9d\u00e9ration hospitalo\u2010universitaire DDS\u2010net, European reference network BOND, Department of Dental Medicine Bretonneau Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-002X","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Linglart","sequence":"additional","affiliation":[{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, Endo\u2010European reference network and European reference network BOND, Department of Endocrinology and Diabetology for Children Bic\u00eatre Paris Saclay Hospital  Le Kremlin Bic\u00eatre France"},{"name":"Universit\u00e9 Paris Saclay Institut national de la sant\u00e9 et de la recherche m\u00e9dicale unit\u00e9 mixte de recherche 1185 Physiologie et physiopathologie endocrinienne  Le Kremlin Bic\u00eatre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chaussain","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 Facult\u00e9 de Sant\u00e9 (Unit\u00e9 de formation et de recherche Odontologie et Unit\u00e9 de formation et de recherche de m\u00e9decine)  Paris France"},{"name":"Assistance publique des hopitaux de Paris, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, F\u00e9d\u00e9ration hospitalo\u2010universitaire DDS\u2010net, European reference network BOND, Department of Dental Medicine Bretonneau Hospital  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9 Laboratory Unit\u00e9 de recherche2496 Orofacial Pathologies, Imaging and Biotherapies  Paris 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