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Twenty DMD boys were enrolled, all ambulant and treated with glucocorticoids (mean age 7.6, height\u2010adjusted\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010scores [HAZ] of hip bone mineral density [BMD] \u22122.3). Ten DMD boys were assigned to stand for 10\u2009min\/d on an active LIV platform (0.4\u2009g at 30\u2009Hz), while 10 stood on a placebo device. Baseline and 14\u2010month bone mineral content (BMC) and BMD of spine, hip, and total body were measured with DXA, and trabecular bone density (TBD) of tibia with quantitative computed tomography (QCT). All children tolerated the LIV intervention well, with daily compliance averaging 78%. At 14\u2009months, TBD in the proximal and distal tibia remained unchanged in placebo subjects (\u22121.0% and \u22120.2%), while rising 3.5% and 4.6% in LIV subjects. HAZ for hip BMD and BMC in the placebo group declined 22% and 13%, respectively, contrasting with no change from baseline (0.9% and 1.4%) in the LIV group. Fat mass in the leg increased 32% in the placebo group, contrasting with 21% in LIV subjects. Across the 14\u2010month study, there were four incident fractures in three placebo patients (30%), with no new fractures identified in LIV subjects. Despite these encouraging results, a major limitation of the study is\u2014despite randomized enrollment\u2014that there was a significant difference in age between the two cohorts, with the LIV group being 2.8y older, and thus at greater severity of disease. In sum, these data suggest that noninvasive LIV can help protect the skeleton of DMD children against the disease progression, the consequences of diminished load bearing, and the complications of chronic steroid use. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10685","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T04:38:06Z","timestamp":1664080686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low\u2010Intensity Vibration Protects the Weight\u2010Bearing Skeleton and Suppresses Fracture Incidence in Boys With Duchenne Muscular Dystrophy: A Prospective, Randomized,\n                    <scp>Double\u2010Blind,<\/scp>\n                    Placebo\u2010Controlled Clinical Trial"],"prefix":"10.1093","volume":"6","author":[{"given":"Maria Luisa","family":"Bianchi","sequence":"first","affiliation":[{"name":"Experimental Laboratory for Children's Bone Metabolism Research Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Vai","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Children's Bone Metabolism Research Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Baranello","sequence":"additional","affiliation":[{"name":"UO Neurologia dello Sviluppo Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"},{"name":"The Dubowitz Neuromuscular Centre UCL NIHR GOSH Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Broggi","sequence":"additional","affiliation":[{"name":"Experimental Laboratory for Children's Bone Metabolism Research Bone Metabolism Unit, Istituto Auxologico Italiano IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Judex","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Stony Brook University  Stony Brook NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hangartner","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Industrial &amp; Human Factors Engineering BioMedical Imaging Laboratory, Wright State University  Dayton OH 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