{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:24:47Z","timestamp":1792160687123,"version":"4.4.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG036675"],"award-info":[{"award-number":["AG036675"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG067577"],"award-info":[{"award-number":["AG067577"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Extracellular vesicles (EVs), including exosomes and microvesicles, are released by numerous cell types. EVs are now acknowledged as playing a critical role in cell\u2013cell communication in healthy aging as well as in age\u2010related diseases. Recently it was shown that senescence, a key hallmark of aging, increases the secretion of EVs. Moreover, EVs can transport proteins and microRNAs (miRNAs) that are key components of the senescence\u2010associated secretory phenotype (SASP). Here we review evidence that SASP\u2010related miRNAs are involved in musculoskeletal degeneration with aging. Specifically, senescence\u2010related miRNAs are elevated in EVs released by skeletal muscle myocytes and fibro\u2010adipogenic progenitor cells with aging and disuse atrophy, respectively. Many of these same senescence\u2010related miRNAs are detected in EVs from the synovial fluid of patients with osteoarthritis, and these miRNAs can contribute to cartilage degeneration. Finally, senescence\u2010associated miRNAs are secreted from bone marrow\u2013derived stem (stromal) cells impacting neighboring hematopoietic stem cells and circulating in the blood. The senescence\u2010associated miRNA mir\u201034a, which is known to target Wnt and Notch pathways as well as the cell survival factors Sirt1 and Bcl2, is detected in EVs from human and animal subjects with muscle atrophy, bone loss, and osteoarthritis. These findings suggest that suppressing the secretion of EV\u2010derived, senescence\u2010related miRNAs, such as miR\u201034a, or increasing levels of competing endogenous long noncoding RNAs, such as MALAT1 that inhibit miR\u201034a, may help to improve musculoskeletal function with aging. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10686","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:54:00Z","timestamp":1664499240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging"],"prefix":"10.1093","volume":"6","author":[{"given":"Monica Correa","family":"Alfonzo","sequence":"first","affiliation":[{"name":"Universidad Central del Caribe  Bayam\u00f3n Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-5317","authenticated-orcid":false,"given":"Ahmed","family":"Al Saedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School and Division of Endocrinology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-6759","authenticated-orcid":false,"given":"Sadanand","family":"Fulzele","sequence":"additional","affiliation":[{"name":"Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-3121","authenticated-orcid":false,"given":"Mark W.","family":"Hamrick","sequence":"additional","affiliation":[{"name":"Medical College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.17.204891"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.20437"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13363"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3569"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8943"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.05.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00143-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22380-3_11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2017.03.008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-022-09972-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001450"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.11.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102547"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000599"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101874"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00177.2021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125019"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084153"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125094"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00828"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M070664"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97949"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153124"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010037"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S169202"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11919"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.620899"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29312"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2021.03.003"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050863"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.790437"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.04.009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1178-8"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.09.006"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01905-y"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05443-1"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41552"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00533-7"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05089-w"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00537-7"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115248"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.770941"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2016.0525"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12794"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10872"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.892661"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2756"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0187-x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1615"},{"issue":"2020","key":"e_1_2_6_53_1","first-page":"3431828","article-title":"Circulating miR\u201034a and bone mineral density of Brazilian very\u2010old adults","author":"N\u00f3brega OT","year":"2020","journal-title":"J Aging Res"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4276"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29191-x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2022.06.002"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00107"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110637"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4385"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S263756"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.017"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26411-7"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-03979-4"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.742004"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12115"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003368"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2021-0069"},{"key":"e_1_2_6_68_1","first-page":"53(5):446\u2010452","article-title":"Plasma LncRNA MALAT1 expressions are negatively associated with disease severity of postmenopausal osteoporosis","author":"Qian TY","year":"2022","journal-title":"Lab Med"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051628"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.772002"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041539"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm4.10686","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm4.10686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:57:37Z","timestamp":1710410257000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/7478988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/jbm4.10686"],"URL":"https:\/\/doi.org\/10.1002\/jbm4.10686","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBM4.10686\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10686\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10686\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBM4.10686\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2473-4039","2473-4039"],"issn-type":[{"value":"2473-4039","type":"print"},{"value":"2473-4039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"2022-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10686"}}