{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:42Z","timestamp":1789588422642,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There is controversy regarding the association between nonalcoholic fatty liver disease (NAFLD) and osteoporosis. Our study aim was to assess bone mineral density (BMD) in patients with biopsy\u2010proven NAFLD and examine if the severity of NAFLD affects BMD. A total of 147 adult women (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u2009108) and men (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200939) aged 18\u201376\u2009years (mean \u00b1 standard deviation [SD] age 45.3\u2009\u00b1\u200912.5) were recruited in this cross\u2010sectional study and underwent a liver biopsy and dual\u2010energy X\u2010ray absorptiometry (DXA). NAFLD activity score (NAS) based on the degree of steatosis, lobular inflammation and hepatocellular ballooning was used to assess NAFLD severity. The majority of subjects, 53%, had steatosis, 25% had nonalcoholic steatohepatitis (NASH) whereas 23% served as control subjects with no evidence of NAFLD. There were no significant differences in the lumbar spine (1.09\u2009\u00b1\u20090.12, 1.11\u2009\u00b1\u20090.18, and 1.12\u2009\u00b1\u20090.15\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.69, in controls, steatosis, and NASH, respectively) or hip BMD (1.10\u2009\u00b1\u20090.15, 1.12\u2009\u00b1\u20090.13, and 1.09\u2009\u00b1\u20090.13\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.48, in controls, steatosis, and NASH, respectively) between the groups. Adjusting for age, gender, body mass index, and diabetes in multiple regression models did not alter the results. There was no correlation between NAS and neither lumbar spine BMD (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u20090.06,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.471), nor hip BMD (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u2009\u22120.03,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.716). In conclusion, BMD was similar across the spectrum of NAFLD in both genders and not related to the severity of the underlying histological lesions, suggesting that neither steatosis nor NASH exerts a detrimental effect on BMD in these relatively young patients. \u00a9 2022 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10714","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:30:55Z","timestamp":1671496255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Are Nonalcoholic Fatty Liver Disease and Bone Mineral Density Associated? \u2014 A Cross\u2010Sectional Study Using Liver Biopsy and Dual\u2010Energy X\u2010Ray Absorptiometry"],"prefix":"10.1093","volume":"7","author":[{"given":"Stinus Gadegaard","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Wilhelmina","family":"Wernberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"},{"name":"Open Patient data Explorative Network (OPEN) Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Ladegaard","family":"Gr\u00f8nkj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte Gade","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Di","family":"Caterino","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Krag","sequence":"additional","affiliation":[{"name":"Center for Liver Research FLASH (Fibrosis Fatty Liver and Steatohepatitis Research Centre) Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Bogh","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"},{"name":"Steno Diabetes Center Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Munk","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg Denmark"},{"name":"Open Patient data Explorative Network (OPEN) Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-2808","authenticated-orcid":false,"given":"Vikram V.","family":"Shanbhogue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sydvestjysk Sygehus Syddansk Universitetshospital  Esbjerg 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