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Mutations in PHEX gene (located at Xp22.1) in XLH alter bone mineral metabolism, resulting in diverse skeletal, dental, and other extraskeletal abnormalities that become evident in early childhood and persist into adolescence and adult life. XLH impacts physical function, mobility, and quality of life, and is associated with substantial socioeconomic burden and health care resource utilization. As the burden of illness varies with age, an appropriate transition of care from childhood and adolescence to adulthood is necessary to meet growth\u2010related changes and minimize long\u2010term sequelae of the condition. Previous XLH guidelines that encompassed transition of care have focused on Western experience. Regional differences in resource availability warrant tailoring of recommendations to the Asia\u2010Pacific (APAC) context. Hence, a core expert panel of 15 pediatric and adult endocrinologists from nine countries\/regions across APAC convened to formulate evidence\u2010based recommendations for optimizing XLH care. A comprehensive literature search on PubMed using MeSH and free\u2010text terms relevant to predetermined clinical questions on diagnosis, multidisciplinary management, and transition of care of XLH revealed 2171 abstracts. The abstracts were reviewed independently by two authors to shortlist a final of 164 articles. A total of 92 full\u2010text articles were finally selected for data extraction and drafting the consensus statements. Sixteen guiding statements were developed based on review of evidence and real\u2010world clinical experience. The GRADE criteria were used to appraise the quality of evidence supporting the statements. Subsequently, a Delphi technique was utilized to rate the agreement on statements; 38 XLH experts (15 core, 20 additional, 3 international) from 15 countries\/regions (12 APAC, 3 EU) participated in the Delphi voting to further refine the statements. Statements 1\u20133 cover the screening and diagnosis of pediatric and adult XLH; we have defined the clinical, imaging, biochemical, and genetic criteria and raised red flags for the presumptive and confirmatory diagnosis of XLH. Statements 4\u201312 tackle elements of multidisciplinary management in XLH such as therapeutic goals and options, composition of the multidisciplinary team, follow\u2010up assessments, required monitoring schedules, and the role of telemedicine. Treatment with active vitamin D, oral phosphate, and burosumab is discussed in terms of applicability to APAC settings. We also expound on multidisciplinary care for different age groups (children, adolescents, adults) and pregnant or lactating women. Statements 13\u201315 address facets of the transition from pediatric to adult care: targets and timelines, roles and responsibilities of stakeholders, and process flow. We explain the use of validated questionnaires, desirable characteristics of a transition care clinic, and important components of a transfer letter. Lastly, strategies to improve XLH education to the medical community are also elaborated in statement 16. Overall, optimized care for XLH patients requires prompt diagnosis, timely multidisciplinary care, and a seamless transfer of care through the coordinated effort of pediatric and adult health care providers, nurse practitioners, parents or caregivers, and patients. To achieve this end, we provide specific guidance for clinical practice in APAC settings. \u00a9 2023 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10744","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T06:31:14Z","timestamp":1679985074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Asia\u2010Pacific Consensus Recommendations on X\u2010Linked Hypophosphatemia: Diagnosis, Multidisciplinary Management, and Transition From Pediatric to Adult Care"],"prefix":"10.1093","volume":"7","author":[{"given":"Craig F","family":"Munns","sequence":"first","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Australia"},{"name":"Department of Endocrinology and Diabetes Queensland Children's Hospital  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Wook","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Bundang CHA Medical Center, CHA University School of Medicine  Seongnam\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Yazid","family":"Jalaludin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashida","family":"Vasanwala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Medicine Endocrine &amp; 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