{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:28Z","timestamp":1772118688538,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human skeletal hemodynamics remain understudied. Neither assessments in weight\u2010bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient\u2010artery characteristics after short\u2010duration unloading in rodents. We studied 12 older adults (8 females, aged 59\u2009\u00b1\u20093\u2009years) who participated in ambulatory near\u2010infrared spectroscopy (NIRS) assessments of tibial hemodynamics before (PRE) and after (POST) 14\u2009days of head\u2010down bed rest (HDBR), with most performing daily resistance and aerobic exercise countermeasures during HDBR. Continual simultaneous NIRS recordings were acquired over the proximal anteromedial tibial prominence of the right lower leg and ipsilateral lateral head of the gastrocnemius muscle during supine rest, walking, and standing. During 10 minutes of walking, desaturation kinetics in the tibia were slower (time to 95% nadir values 125.4\u2009\u00b1\u200956.8\u2009s versus 55.0\u2009\u00b1\u200930.1\u2009s,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0014). Tibial tissue saturation index (TSI) immediately fell (\u22129.9\u2009\u00b1\u20094.55) and did not completely recover by the end of 10 minutes of walking (\u22127.4\u2009\u00b1\u20096.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). Upon standing, total hemoglobin (tHb) kinetics were faster in the tibia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), whereas HDBR resulted in faster oxygenated hemoglogin (O\n                    <jats:sub>2<\/jats:sub>\n                    Hb) kinetics in both tissues (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.039). After the walk\u2010to\u2010stand transition, changes in O\n                    <jats:sub>2<\/jats:sub>\n                    Hb (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0022) and tHb (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0047) were attenuated in the tibia alone after bed rest. Comparisons of NIRS\u2010derived variables during ambulation and changes in posture revealed potentially deleterious adaptations of feed vessels after HDBR. We identify important and novel tibial hemodynamics in humans during ambulation before and after bed rest, necessitating further investigation. \u00a9 2023 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10756","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T19:44:56Z","timestamp":1683056696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14\u2009Days of Head\u2010Down Bed Rest"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-4533","authenticated-orcid":false,"given":"Eric T","family":"Hedge","sequence":"first","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Canada"},{"name":"Department of Kinesiology and Health Sciences University of Waterloo Waterloo Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-287X","authenticated-orcid":false,"given":"Laurence","family":"Vico","sequence":"additional","affiliation":[{"name":"U1059 INSERM\u2014SAINBIOSE (Sant\u00e9 Ing\u00e9ni\u00e9rie Biologie St\u2010Etienne) Campus Sant\u00e9 Innovation Universit\u00e9 Jean Monnet Saint\u2010Priest\u2010en\u2010Jarez France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-2959","authenticated-orcid":false,"given":"Richard L","family":"Hughson","sequence":"additional","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-6639","authenticated-orcid":false,"given":"Carmelo J","family":"Mastrandrea","sequence":"additional","affiliation":[{"name":"Schlegel\u2010UW Research Institute for Aging Waterloo Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X11430858"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/jbm.23390"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00935.2015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.BR02.2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2018.37"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.11.034"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"122","article-title":"One mechanostat or many? 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