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A potentially pathogenic germline variant in the runt\u2010related transcription factor 1 (RUNX1) gene was discovered by a focused 51\u2010gene myeloid malignancy panel during investigation for his unexplained normochromic normocytic anemia. Further bone\u2010specific genetic testing and a pedigree analysis were declined by the patient. Recent experimental evidence demonstrates that RUNX1 plays a key role in the regulation of osteogenesis and bone homeostasis during skeletal development, mediated by the bone morphogenic protein and Wnt signaling pathways. Therefore, rarer causes of osteoporosis, including those affecting bone formation, should be considered in young patients with multiple unexpected minimal trauma fractures. \u00a9 2023 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10791","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T03:41:25Z","timestamp":1690602085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel\n                    <scp>RUNX1<\/scp>\n                    Genetic Variant Identified in a Young Male with Severe Osteoporosis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-1137","authenticated-orcid":false,"given":"Tomasz 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