{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:53Z","timestamp":1786977953350,"version":"build-2736575974"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007214","name":"Velux Stiftung","doi-asserted-by":"publisher","award":["VELUX25723"],"award-info":[{"award-number":["VELUX25723"]}],"id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["10\u2010001584"],"award-info":[{"award-number":["10\u2010001584"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JBMR Plus"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In hypoparathyroidism, lack of parathyroid hormone (PTH) leads to low calcium levels and decreased bone remodeling. Treatment with recombinant human PTH (rhPTH) may normalize bone turnover. This study aimed to investigate whether rhPTH(1\u201384) continued to activate intracortical bone remodeling after 30\u2009months and promoted the transition from erosion to formation and whether this effect was transitory when rhPTH(1\u201384) was discontinued. Cortical histomorphometry was performed on 60 bone biopsies from patients (aged 31 to 78\u2009years) with chronic hypoparathyroidism randomized to either 100\u2009\u03bcg rhPTH(1\u201384) a day (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921) (PTH) or similar placebo (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200921) (PLB) for 6\u2009months as add\u2010on to conventional therapy. This was followed by an open\u2010label extension, where patients extended their rhPTH(1\u201384) (PTH) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), continued conventional treatment (CON) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20095), or withdrew from rhPTH(1\u201384) and resumed conventional therapy (PTHw) for an additional 24\u2009months (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20098). Bone biopsies were collected at months 6 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200942) and 30 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200918). After 6 and 30\u2009months, the overall cortical microarchitecture (cortical porosity, thickness, pore density, and mean pore diameter) in the PTH group did not differ from that of the PLB\/CON and PTHw groups. Still, the PTH group had a significantly and persistently higher percentage of pores undergoing remodeling than the PLB\/CON groups. A significantly higher percentage of these pores was undergoing bone formation in the PTH compared with the PLB\/CON groups, whereas the percentage of pores with erosion only was not different. This resulted in a shift in the ratio between formative and eroded pores, reflecting a faster transition from erosion to formation in the PTH\u2010treated patients. In the rhPTH(1\u201384) withdrawal group PTHw, the latter effects of PTH were completely reversed in comparison to those of the PLB\/CON groups. In conclusion, rhPTH(1\u201384) replacement therapy in hypoparathyroidism patients promotes intracortical remodeling and its transition from erosion to formation without affecting the overall cortical microstructure. The effect persists for at least 30\u2009months and is reversible when treatment is withdrawn. \u00a9 2023 The Authors.\n                    <jats:italic>JBMR Plus<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.\n                  <\/jats:p>","DOI":"10.1002\/jbm4.10829","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:30:20Z","timestamp":1700213420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transitory Activation and Improved Transition from Erosion to Formation within Intracortical Bone Remodeling in Hypoparathyroid Patients Treated with\n                    <scp>rhPTH<\/scp>\n                    (1\u201384)"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-1232","authenticated-orcid":false,"given":"Pernille","family":"van Dijk Christiansen","sequence":"first","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"},{"name":"Molecular Bone Histology (MBH) Lab, Research Unit of Pathology, Department of Clinical Research and Department of Molecular Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-9570","authenticated-orcid":false,"given":"Tanja","family":"Sikj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-5677","authenticated-orcid":false,"given":"Christina M\u00f8ller","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  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Margrethe","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-1500","authenticated-orcid":false,"given":"Jean\u2010Marie","family":"Delaisse","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"},{"name":"Molecular Bone Histology (MBH) Lab, Research Unit of Pathology, Department of Clinical Research and Department of Molecular Medicine University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4247","authenticated-orcid":false,"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University 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